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[reaction: see text] A new fluorescent probe, salicylaldehyde rhodamine B hydrazone (1), was synthesized and displayed selective Cu(II)-amplified absorbance and fluorescence emission above 500 nm in neutral buffered media. Upon the addition of Cu(II), the spirolactam ring of 1 was opened and a 1:1 metal-ligand complex was formed. The detection of Cu(II) by(More)
BACKGROUND Fatigue is a common problem in ischemic stroke survivors. The mechanisms of poststroke fatigue are uncertain yet. The effects of it on functional status have rarely been studied. AIMS The aim of this study was to investigate the risk factors of poststroke fatigue and its effect on activities of daily living and health-related quality of life in(More)
Portable, low-cost and quantitative detection of a broad range of targets at home and in the field has the potential to revolutionize medical diagnostics and environmental monitoring. Despite many years of research, very few such devices are commercially available. Taking advantage of the wide availability and low cost of the pocket-sized personal glucose(More)
An abasic site called dSpacer has been introduced into duplex regions of the 8-17 DNAzyme and adenosine aptamer for label-free fluorescent detection of Pb(2+) and adenosine, respectively. The dSpacer can bind an extrinsic fluorescent compound, 2-amino-5,6,7-trimethyl-1,8-naphthyridine (ATMND), and quench its fluorescence. Addition of Pb(2+) enables the(More)
Increasing interest in detecting metal ions in many chemical and biomedical fields has created demands for developing sensors and imaging agents for metal ions with high sensitivity and selectivity. This review covers recent progress in DNA-based sensors and imaging agents for metal ions. Through both combinatorial selection and rational design, a number of(More)
DNA detection is commonly used in molecular biology, pathogen analysis, genetic disorder diagnosis, and forensic tests. While traditional methods for DNA detection such as polymerase chain reaction (PCR) and DNA microarrays have been well developed, they require sophisticated equipment and operations, and thus it is still challenging to develop a portable(More)
A series of salicylaldehyde azine derivatives were found to exhibit interesting aggregation-induced emission enhancement (AIEE) characteristics. In good solvent, all these compounds displayed very weak fluorescence, while strong emission was observed when they were placed in poor solvent. Moreover, the AIEE color of these compounds varied from green to red(More)
Previously, we reported that MYC oncoprotein down-regulates the transcription of human MC-let-7a-1~let-7d microRNA cluster in hepatocarcinoma (HCC). Surprisingly, in silico analysis indicated that let-7 miRNA expression levels are not reduced in glioblastoma (GBM). Here we investigated the molecular basis of this differential expression. Using human GBM U87(More)
[structure: see text] A new fluorescent probe 3 was synthesized, and it exhibited high selectivity for Fe(III) over other commonly coexistent metal ions in both ethanol and water. Upon the addition of Fe(III), the spirocyclic ring of 3 was opened and a significant enhancement of visible color and fluorescence in the range of 500-600 nm was observed.
A highly selective and sensitive rhodamine-based colorimetric chemosensor (1) for quantification of divalent copper in aqueous solution has been investigated in this work. It was designed using salicylaldehyde hydrazone and rhodamine 6G as copper-chelating and signal-reporting groups, respectively. In environmentally friendly media (50%(v/v) water/ethanol(More)