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BACKGROUND AND OBJECTIVE Concern has been expressed over the cardiovascular risks associated with rosiglitazone and pioglitazone. This study investigates the association between oral antihyperglycaemics (rosiglitazone, pioglitazone, sulfonylureas and metformin) with myocardial infarction, congestive heart failure, angina pectoris, stroke and transient(More)
BACKGROUND Using national data (2001-2003), this study explored the risk of acute myocardial infarction (AMI), angina, stroke and transient ischaemic attack (TIA) in long-term users of rofecoxib and celecoxib in Taiwan and compared this data with that for those using meloxicam. METHODS Patients included in the study had used celecoxib, rofecoxib or(More)
OBJECTIVES To assess the costs of the health effects of cigarette smoking and secondhand smoke (SHS) exposure to society. DESIGN Prevalence-based, disease-specific cost-of-illness study. We used an epidemiological population-attributable risk method to determine the costs that can be attributed to smoking and SHS exposure. SETTING Taiwan. PARTICIPANTS(More)
BACKGROUND A link between the use of alendronate and atypical diaphyseal femoral fracture has been suggested. OBJECTIVE The goal of this study was to evaluate the benefits of alendronate in preventing rehospitalization due to hip fractures and whether its use increases risk of hospitalization for atypical diaphyseal femoral fractures in Taiwan. METHODS(More)
Concomitant use of antiplatelet agents and proton-pump inhibitors (PPIs) has been recommended in patients with a history of gastrointestinal (GI) hemorrhage. However, recent studies have reported that PPIs may alter clopidogrel’s pharmacokinetics and potentially lead to an increased risk of recurrent adverse cardiovascular (CV) events. Using Taiwan’s(More)
BACKGROUND Polypharmacy, potentially inappropriate medications and anticholinergic burden (as assessed by the anticholinergic risk scale) are commonly used as quality indicators of pharmacotherapy in older adults. However, their role in clinical practice is undefined. We sought to investigate longitudinal changes in these indicators and their effects on(More)
OBJECTIVE To evaluate the outcome of vertebroplasty or kyphoplasty (VK), in comparison with non-VK treatment, among patients hospitalized for first-ever vertebral compression fractures (VCFs). DESIGN A population-based retrospective cohort study. SETTING Taiwan' s National Health Insurance claims data. PARTICIPANTS All individuals aged ≥ 60 years who(More)
OBJECTIVES Concerns have been raised about bisphosphonate use and risk of atrial fibrillation (AF) in women with osteoporosis. This study compares the risk of AF and of flutter or acute myocardial infarction (AMI) in women with osteoporosis taking alendronate or raloxifene. METHODS Using Taiwan's National Health Insurance database to conduct a(More)
BACKGROUND Psoriasis is associated with cardiovascular morbidity and mortality. However, the association between psoriasis and arrhythmia has not been adequately studied. OBJECTIVE We sought to investigate whether patients with psoriasis have an increased risk of arrhythmia. METHODS This population-based cohort study identified 40,637 patients with(More)
STUDY OBJECTIVE To compare Helicobacter pylori eradication therapy with antisecretory therapy alone on the risk of hospitalization for a major ulcer event. DESIGN Retrospective, population-based cohort study. DATA SOURCE The 2000-2006 National Health Insurance database in Taiwan. PATIENTS A total of 838,176 patients diagnosed with a gastrointestinal(More)