Yu-Tung Chien

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Enzymes play important roles in most of the biological processes. Although only a small fraction of residues are directly involved in catalytic reactions, these catalytic residues are the most crucial parts in enzymes. The study of the fundamental and unique features of catalytic residues benefits the understanding of enzyme functions and catalytic(More)
Prediction of protein catalytic residues provides useful information for the studies of protein functions. Most of the existing methods combine both structure and sequence information but heavily rely on sequence conservation from multiple sequence alignments. The contribution of structure information is usually less than that of sequence conservation in(More)
Due to the large number of protein structures whose functions are unknown, it becomes increasing important to study the structural characteristics of catalytic residues. Here, we use a novel method to calculate the local structural rigidity (LSR) of protein. Based on a dataset of 760 proteins, the results show that catalytic residues have distinct(More)
We propose a method (EXIA2) of catalytic residue prediction based on protein structure without needing homology information. The method is based on the special side chain orientation of catalytic residues. We found that the side chain of catalytic residues usually points to the center of the catalytic site. The special orientation is usually observed in(More)
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