Yu-Ting Tang

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The in vivo characterization of a dual adenosine A(2A)/A(1) receptor antagonist in several animal models of Parkinson's disease is described. Discovery and scale-up syntheses of compound 1 are described in detail, highlighting optimization steps that increased the overall yield of 1 from 10.0% to 30.5%. Compound 1 is a potent A(2A)/A(1) receptor antagonist(More)
Adenosine A(2a) receptor (A(2a)R) colocalizes with dopamine D(2) receptor (D(2)R) in the basal ganglia and modulates D(2)R-mediated dopaminergic activities. A(2a)R and D(2)R couple to stimulatory and inhibitory G proteins, respectively. Their opposing roles in regulating neuronal activities, such as locomotion and alcohol consumption, are mediated by their(More)
Considering the limited resources and the dynamic spectrum distribution in the cognitive radio sensor networks (CRSN), a half-duplex Multichannel broadcast protocol for CRSN is presented based on the home channel. This protocol maintains the networks topology only through the home channel, so there is no need for the public channel to transmit the control(More)
With the aim of discovering new anticancer agents, we have designed and synthesized novel α-aminophosphonate derivatives containing a 2-oxoquinoline structure using a convenient one-pot three-component method. The newly synthesized compounds were evaluated for antitumor activities against the A549 (human lung adenocarcinoma cell), HeLa (human cervical(More)
The neural network with two weights is constructed and its approximation ability to any continuous functions is proved. For this neural network, the activation function is not confined to the odd functions. We prove that it can limitlessly approach any continuous function from limited close subset of R(m) to R(n) and any continuous function, which has limit(More)
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