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Higher specificity of the activity of low molecular weight fucoidan for thrombin-induced platelet aggregation.
TLDR
Results indicate that F-Q inhibits thrombin via activation of AT and HCII, whereas F-S mainly interacts directly withThrombin, and shows a higher specificity for hypoaggregation and a weaker effect for anticoagulant profiles than heparin andF-S.
The discovery of Yuanzhi-1, a triterpenoid saponin derived from the traditional Chinese medicine, has antidepressant-like activity
TLDR
It is demonstrated that Yuanzhi-1 has a potential to be a novel triple monoamine reuptake inhibitor of antidepressant-like activity.
The antidepressant-like pharmacological profile of Yuanzhi-1, a novel serotonin, norepinephrine and dopamine reuptake inhibitor
TLDR
In vivo microdialysis studies showed that 5- and 10-mg/kg administrations of Yuanzhi-1 significantly increased the extracellular concentrations of 5-HT, NE and DA in the frontal cortices of freely moving rats and might represent a novel triple reuptake inhibitor and possess antidepressant-like activity.
Proliferative inhibition of danxiongfang and its active ingredients on rat vascular smooth muscle cell and protective effect on the VSMC damage induced by hydrogen peroxide.
TLDR
The results suggest that DSS, CT, FA and DF inhibited VSMC proliferation by increasing the NO level and decreasing the ET-1 content, providing a pharmacological foundation for the clinical use of DF in the prevention and treatment of hyperlipidemia and atherosclerosis relevant to endothelial cell proliferation and damage.
Anxiolytic effects of GLYX-13 in animal models of posttraumatic stress disorder-like behavior
TLDR
The results suggest that GLYX-13 exerts a therapeutic effect on PTSD-like stress responding that is accompanied by (or associated with) modulation of the HPA axis, including inhibition of stress hormone levels and upregulation of hippocampal GR expression.
Increases in tumor markers are associated with primary Sjögren’s syndrome-associated interstitial lung disease
TLDR
Higher CA153 levels are significantly correlated to the increased risk of ILD in patients with pSS and may be directly involved in the pathogenesis of pSS-ILD.
Correlation between the distribution of intracranial and extracranial aterial lesions and risk factors in Chinese patients with ischemic stroke: a multicenter registry study
TLDR
There are significant differences in the distribution characteristics and risk factors of intracranial and extracranial aterial lesions in patients with ischemic stroke in China.
Evaluation of the structure and hemodynamics of internal jugular veins by ultrasound in normal population
TLDR
Color Doppler flow imaging can evaluate the IJV structures and hemodynamics by assessing the diameter, CSA, Vmax, FVm and PGmax, and right IJV is the dominated outflow side in normal population.
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