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Guidelines for the communication of Biomonitoring Equivalents: report from the Biomonitoring Equivalents Expert Workshop.
TLDR
This paper provides guidance on methods for conveying information to the general public, the health care community, regulators and other interested parties regarding how chemical-specific BEs are derived, what they mean in terms of health, and the challenges and questions related to interpretation and communication of biomonitoring data. Expand
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A novel amperometric immunosensor based on Fe3O4 magnetic nanoparticles/chitosan composite film for determination of ferritin
A novel amperometric immunosensor was developed by immobilizing ferritin antibody (FeAb) on the surface of Fe3O4 magnetic nanoparticles/chitosan composite film modified glassy carbon electrode (GCE).Expand
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Completing the Link between Exposure Science and Toxicology for Improved Environmental Health Decision Making: The Aggregate Exposure Pathway Framework.
Driven by major scientific advances in analytical methods, biomonitoring, computation, and a newly articulated vision for a greater impact in public health, the field of exposure science isExpand
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Uses of NHANES Biomarker Data for Chemical Risk Assessment: Trends, Challenges, and Opportunities
Background Each year, the U.S. NHANES measures hundreds of chemical biomarkers in samples from thousands of study participants. These biomarker measurements are used to establish population referenceExpand
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A Workflow to Investigate Exposure and Pharmacokinetic Influences on High-Throughput in Vitro Chemical Screening Based on Adverse Outcome Pathways
Background Adverse outcome pathways (AOPs) link adverse effects in individuals or populations to a molecular initiating event (MIE) that can be quantified using in vitro methods. PracticalExpand
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Sperm DNA damage has a negative effect on early embryonic development following in vitro fertilization
Sperm DNA damage is recognized as an important biomarker of male infertility. To investigate this, sperm DNA damage was assessed by the sperm chromatin dispersion (SCD) test in semen and motileExpand
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Developing a Physiologically-Based Pharmacokinetic Model Knowledgebase in Support of Provisional Model Construction
TLDR
Developing physiologically-based pharmacokinetic (PBPK) models for chemicals can be resource-intensive, as neither chemical-specific parameters nor in vivo pharmacokinetics data are easily available. Expand
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Analysis of biomarker utility using a PBPK/PD model for carbaryl
There are many types of biomarkers; the two common ones are biomarkers of exposure and biomarkers of effect. The utility of a biomarker for estimating exposures or predicting risks depends on theExpand
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Informing mechanistic toxicology with computational molecular models.
TLDR
We describe generalized protocols in which 3D computational molecular modeling is used to enhance our ability to predict and model the most relevant toxicokinetic, metabolic, and molecular toxicological endpoints, thereby accelerating the computational toxicology-driven basis of modern risk assessment. Expand
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