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BACKGROUND Melanoma risk is related to sun exposure; we have investigated risk variation by tumour site and latitude. METHODS We performed a pooled analysis of 15 case-control studies (5700 melanoma cases and 7216 controls), correlating patterns of sun exposure, sunburn and solar keratoses (three studies) with melanoma risk. Pooled odds ratios (pORs) and(More)
BACKGROUND Increased number of melanocytic nevi is a potent melanoma risk factor. We have carried out a large population-based case-control study to explore the environmental and genetic determinants of nevi and the relationship with melanoma risk. METHODS We report nevus phenotype in relation to differing patterns of sun exposure, inherited variation at(More)
While natural selection might in some cases facilitate invasions into novel habitats, few direct measurements of selection response exist for invasive populations. This study examined selection response to changes in salinity using the copepod Eurytemora affinis. This copepod has invaded fresh water from saline habitats multiple times independently(More)
Many of the existing machine-learning approaches to speech summarization cast important sentence selection as a two-class classification problem and have shown empirical success for a wide variety of summarization tasks. However, the imbalanced-data problem sometimes results in a trained speech summarizer with unsatisfactory performance. On the other hand,(More)
The purpose of extractive speech summarization is to automatically select a number of indicative sentences or paragraphs (or audio segments) from the original spoken document according to a target summarization ratio and then concatenate them to form a concise summary. Much work on extractive summarization has been initiated for developing machine-learning(More)
BACKGROUND The incidence of melanoma continues to increase in many countries, and primary prevention of melanoma includes avoidance of sunburn as well as adequate sun protection behavior. The aim of this study was to examine the prevalence of self-reported sun protection behaviors and sunburn in users of the Internet, and to identify the demographic,(More)
We report an investigation of gene dosage at 9p21.3 and mutations in BRAF and NRAS, as predictors of relapse and histological markers of poor melanoma prognosis. Formalin-fixed primary melanomas from 74 relapsed and 42 nonrelapsed patients were sequenced for common BRAF and NRAS mutations (N = 71 results) and gene dosage at 9p21.3 including the genes CDKN2A(More)
Remarkably little has been published on hematological phenotypes of the domestic dog, the most polymorphic species on the planet. Information on the signalment and complete blood cell count of all dogs with normal red and white blood cell parameters judged by existing reference intervals was extracted from a veterinary database. Normal hematological(More)
BACKGROUND We report the determinants of serum levels of vitamin D in a U.K. melanoma case-control study benefitting from detailed exposure and genotyping data. METHODS Sun exposure, supplemental vitamin D, and SNPs reported to be associated with serum levels were assessed as predictors of a single serum 25-hydroxyvitamin D3 measurement adjusted for(More)