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Web 2.0 approaches are revolutionizing the Internet, blurring lines between developers and users and enabling collaboration and social networks that scale into the millions of users. As we have discussed in previous work, the core technologies of Web 2.0 effectively define a comprehensive distributed computing environment that parallels many of the more(More)
The development of cloud infrastructures has stimulated interest in virtualized block storage systems, exemplified by Amazon Elastic Block Store (EBS), Eucalyptus’ EBS implementation, and the Virtual Block Store (VBS) system. Compared with other solutions, VBS is designed for flexibility, and can be extended to support various(More)
Association mapping is an efficient approach for the identification of the molecular basis of agronomic traits in crop plants. For this purpose in pea (Pisum sativum L.), we genotyped and phenotyped individual lines of the single-plant-derived core collection of the USDA pea collection including accessions from 330 landraces and cultivars of Pisum sativum(More)
Mutation testing takes a different approach to testing by asking questions about the efficacy of test cases. The test cases are tested by introducing bugs in the code. The test cases are then run on the original program and all the mutants. The effectiveness of a test case is determined by the percentage of mutants it kills. This report describes a mutation(More)
Human Elongator complex, which plays a key role in transcript elongation in vitro assay, is incredibly similar in either components or function to its yeast counterpart. However, there are only a few studies focusing on its target gene characterization in vivo. We studied the effect of down-regulation of the human elongation protein 3 (hELP3) on the(More)
Computational Grids [Grid, Grid1] have become an important asset in large-scale scientific and engineering research. By providing a set of services that allow a widely distributed collection of resources to be tied together into a relatively seamless computing framework, teams of researchers can collaborate to solve problems that they could not have(More)
Recent success in the derivation of haploid embryonic stem cells (haESCs) from mouse via parthenogenesis and androgenesis has enabled genetic screening in mammalian cells and generation of gene-modified animals. However, whether haESCs can be derived from primates remains unknown. Here, we report the derivation of haESCs from parthenogenetic blastocysts of(More)
In this study, a 3D digital atlas of the live mouse brain based on magnetic resonance microscopy (MRM) is presented. C57BL/6J adult mouse brains were imaged in vivo on a 9.4 Tesla MR instrument at an isotropic spatial resolution of 100 mum. With sufficient signal-to-noise (SNR) and contrast-to-noise ratio (CNR), 20 brain regions were identified. Several(More)
Service-based geographic information system (GIS) technologies can enable an open-architecture cyberinfrastructure to provide standards-compliant data products and computing services for both earthquake research and disaster planning and response. Here, a service-based GIS framework is evaluated using examples from two earthquake science projects: QuakeSim(More)
The reduction of greenhouse gas (GHG) emissions from transportation is essential for achieving politically agreed upon emissions reduction targets that aim to combat global climate change. So-called eco-routing and eco-driving are able to substantially reduce GHG emissions caused by vehicular transportation. To enable these, it is necessary to be able to(More)