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Superoxide Mediates Sympathoexcitation in Heart Failure: Roles of Angiotensin II and NAD(P)H Oxidase
Chronic heart failure (CHF) is often associated with excitation of the sympathetic nervous system. This event is thought to be a negative predictor of survival in CHF. Sympathoexcitation and central… Expand
Simvastatin Therapy Normalizes Sympathetic Neural Control in Experimental Heart Failure: Roles of Angiotensin II Type 1 Receptors and NAD(P)H Oxidase
Background—In a previous study, we showed that simvastatin (SIM) therapy normalized sympathetic outflow and cardiovascular reflex regulation in chronic heart failure (CHF). However, the precise… Expand
Sympathoexcitation by central ANG II: roles for AT1 receptor upregulation and NAD(P)H oxidase in RVLM.
- Lie Gao, W. Wang, +4 authors I. Zucker
- Medicine, Biology
- American journal of physiology. Heart and…
- 1 May 2005
Chronic heart failure is often associated with sympathoexcitation and blunted arterial baroreflex function. These phenomena have been causally linked to elevated central ANG II mechanisms. Recent… Expand
Angiotensin II enhances carotid body chemoreflex control of sympathetic outflow in chronic heart failure rabbits.
OBJECTIVES We investigated whether Angiotensin II (Ang II) modulates peripheral chemoreflex function through carotid body (CB) chemoreceptors in chronic heart failure (CHF). METHODS We measured… Expand
Alteration in skeletal muscle afferents in rats with chronic heart failure
- Han-Jun Wang, Yu-Long Li, Lie Gao, I. Zucker, W. Wang
- Chemistry, Medicine
- The Journal of physiology
- 1 December 2010
An exaggerated exercise pressor reflex (EPR) contributes to exercise intolerance and excessive sympatho‐excitation in the chronic heart failure (CHF) state. However, the components of this reflex… Expand
Gene Transfer of Neuronal Nitric Oxide Synthase to Carotid Body Reverses Enhanced Chemoreceptor Function in Heart Failure Rabbits
Our previous studies showed that decreased nitric oxide (NO) production enhanced carotid body (CB) chemoreceptor activity in chronic heart failure (CHF) rabbits. In the present study, we investigated… Expand
Role of blood flow in carotid body chemoreflex function in heart failure
Activation of the sympathetic nervous system hastens the rate of progression and severity of chronic heart failure (CHF). Chemically sensitive nerves in the carotid body (CB) that stimulate… Expand
Tourniquet-induced acute ischemia-reperfusion injury in mouse skeletal muscles: Involvement of superoxide.
- T. Tran, H. Tu, I. Pipinos, R. Muelleman, H. Albadawi, Yu-Long Li
- European journal of pharmacology
- 10 January 2011
Although arterial limb tourniquet is one of the first-line treatments to prevent exsanguinating hemorrhage in both civilian pre-hospital and battlefield casualty care, prolonged application of a limb… Expand
Exercise training improves peripheral chemoreflex function in heart failure rabbits.
- Yu-Long Li, Y. Ding, C. Agnew, H. Schultz
- Chemistry, Medicine
- Journal of applied physiology
- 1 September 2008
An enhancement of peripheral chemoreflex sensitivity contributes to sympathetic hyperactivity in chronic heart failure (CHF) rabbits. The enhanced chemoreflex function in CHF involves augmented… Expand
Role of CuZn superoxide dismutase on carotid body function in heart failure rabbits.
- Y. Ding, Yu-Long Li, M. Zimmerman, R. Davisson, H. Schultz
- Cardiovascular research
- 17 December 2008
AIMS Peripheral chemoreflex sensitivity is potentiated in both clinical and experimental chronic heart failure (CHF). NADPH oxidase-derived superoxide mediates angiotensin II (Ang II)-enhanced… Expand