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Previous studies have demonstrated that dietary administration of the schistosomicidal drug 5-(2-pyrazinyl)-4-methyl-1,2-dithiole-3-thione (oltipraz) ameliorates the hepatotoxicity of aflatoxin B1 (AFB1). Notably, mortality, altered hepatic function, hepatic AFB1-DNA adduct levels, and expression of hepatic enzyme-altered foci were markedly reduced in the(More)
AIM To analyze the possible protective role of Arctium lappa L. (AL) in a murine model of ulcerative colitis (UC). METHODS BALB/c mice were administered 100 mg/kg AL powder orally each day. After 7 d, colitis was induced by administration of dextran sulfate sodium (DSS) (5% W/V) in drinking water for a further 8 consecutive days. Diarrhea and bloody(More)
A new chemoprotective agent, oltipraz, was evaluated for alleviation of aflatoxin B1-induced hepatotoxicity. Male F344 rats were fed a diet supplemented with 0.075% oltipraz and compared to rats fed the purified diet (AIN) alone. Rats were fed these diets for 1 week prior to treatment with aflatoxin B1 (AFB1) and throughout the experimental period. AFB1 was(More)
BACKGROUND Localized fibrous tumors of the pleura (LFTPs) are uncommon thoracic neoplasms with variable malignant potential that were previously classified as benign presentation of mesothelioma. We investigate the clinical presentation, recurrence patterns, and long-term survival of patients undergoing curative resection of LFTPs. PATIENTS AND METHODS(More)
Feature extraction in clutter is a challenging problem in SAR target recognition because of the difficulty in distinguishing the target signature from the background. In this paper, a new feature extracting algorithm based on automated peak region segmentation (PRS) and regularized orthogonal matching pursuit (ROMP) techniques is presented and called(More)
In order to decrease the toxicity and enhance the curative effect of niridazole against Schistosomiasis japonica, a series of acylates of niridazole has been prepared through acylation of niridazole, 2-substituted acetamido-5-nitrothiazoles and 1-(5-nitro-2-thiazolyl)-4-acylpiperazine were also prepared. The products has been tested against Schistosomiasis(More)
Female rats were fed purified rations containing 20% fat during gestation and lactation. The fat content was butter oil, an equal mixture of butter oil and lard, or safflower oil. Each litter size was reduced (at random) to 2 male and 2 female pups 1 day postpartum, and these offspring were feed a commercial ration after weaning and until they were 20 weeks(More)
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