Learn More
Calcium-activated chloride channels (CaCC) encoded by family members of transmembrane proteins of unknown function 16 (TMEM16) have recently been intensely studied for functional properties as well as their physiological roles as chloride channels in various tissues. One technical hurdle in studying these channels is the well-known channel rundown that(More)
The removal of nucleotides from the solution bathing the inner face of excised patches of frog atrial membranes was found to activate muscarinic K+ channels in the absence of agonists. Channel activation was also observed in Mg2+-free solutions and blocked by low (0.1-10 microM) concentrations of GDP or GTP. After full activation was achieved, channel(More)
  • 1