Yu-Kyung Lee

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Transmembrane protein 106B (TMEM106B) has been identified as a risk factor for frontotemporal lobar degeneration, which is the second most common form of progressive dementia in people under 65 years of age. Mutations in charged multivesicular body protein 2B (CHMP2B), which is involved in endosomal protein trafficking, have been found in chromosome(More)
In this paper, we present quantitative analysis of cardiac images using an efficient physical deformation model to evaluate ventricular function. By using this model we can accurately and efficiently compute ventricular volume, myocardial mass, endo- and epi-cardial wall motions and wall thickness over a full cardiac cycle. Patients with cardiac diseases(More)
KCB-328 [1-(2-amino-4-methanesulfonamidophenoxy)-2-[N-(3,4-dimethoxyphenethyl)-N-methylamino]ethane hydrochloride] is a newly synthesized class III antiarrhythmic drug and is known to be highly effective against various types of arrhythmias induced by coronary artery ligation, reperfusion, and programmed electrical stimulation. To understand the potential(More)
Papaverine, 1-[(3,4-dimethoxyphenyl)methyl]-6,-7-dimethoxyisoquinoline, has been used as a vasodilator agent and a therapeutic agent for cerebral vasospasm, renal colic, and penile impotence. We examined the effects of papaverine on a rapidly activating delayed rectifier K(+) channel (hKv1.5) cloned from human heart and stably expressed in Ltk(-) cells as(More)
1. Nano-Bio EM Research Group, Korea Basic Science Institute, 169-148 Gwahak-ro, Yuseong-gu, Daejeon, Korea. 2. Department of Biological Sciences and Biotechnology, College of Life Sciences and Nanotechnology, Hannam University, Daejeon, Korea. 3. Department of Applied Biology, College of Ecology and Environment, Kyungpook National University, Sang-ju,(More)
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