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OBJECTIVES To investigate prescribers' rationales for overriding drug-drug interaction (DDI) alerts and to determine whether these reasons were helpful to pharmacists as a part of prescription order verification. STUDY DESIGN An observational retrospective database analysis was conducted using override reasons derived from a computerized system at 6(More)
BACKGROUND Given the high prevalence of medication use in the US, the risk of drug-drug interactions (DDIs) and potential for patient harm is of concern. Despite the rise in technologies to identify potential DDIs, the ability of physicians and other prescribers to recognize potential DDIs is essential to reduce their occurrence. The objectives of this(More)
OBJECTIVE Diagram patients' views of the causes of adverse drug events (ADEs) in ambulatory care, examine characteristics of causes reported by patients, and identify those that have been studied in the medical and social science literatures. METHODS Twenty-two primary care patients were interviewed using a root cause analysis approach. Diagrams derived(More)
OBJECTIVE To examine health-related quality of life (HRQoL) after total knee replacement (TKR) or unicompartmental knee arthroplasty (UKA). METHODS Asian adult patients undergoing either TKR or UKA in a hospital in Singapore between 2001 and 2006 were interviewed before surgery and 6 and 24 months postoperatively to obtain demographic information and(More)
OBJECTIVES To assess Veterans Affairs (VA) prescribers' and pharmacists' opinions about computer-generated drug-drug interaction (DDI) alerts and obtain suggestions for improving DDI alerts. DESIGN A mail survey of 725 prescribers and 142 pharmacists from seven VA medical centers across the United States. MEASUREMENTS A questionnaire asked respondents(More)
OBJECTIVES To investigate the impact of urinary incontinence (UI) on health-related quality of life (QOL), as measured by the Medical Outcomes Study Short Form-36 (SF-36) and to compare UI and non-UI elderly Medicare beneficiaries enrolled in managed care plans on the prevalence of depression and self-rated health. METHODS After excluding beneficiaries(More)
BACKGROUND Given the rate at which new medications are introduced to the market, as well as the diversity of existing drugs, pharmacists frequently need to consult drug information (DI) sources. Currently, there is a lack of information about pharmacists' needs for and sources of DI in Singapore. OBJECTIVE To examine where practicing pharmacists in(More)
OBJECTIVES To estimate the prevalence of chronic conditions in managed care-enrolled Medicare seniors (age 65 years plus) and to examine the association between self-reported chronic conditions and health status, as measured by the SF-36. METHODS Data were obtained from the 2001 Medicare Health Outcomes Survey (HOS). The HOS is conducted to assess the(More)
OBJECTIVE To examine the unique health-related quality of life (HRQoL) decrements associated with common chronic conditions in the general US adult population. METHODS Data were obtained from a study aimed at establishing a US population-based set of preference weights for the health states defined by the EQ-5D. The EQ-5D is a brief, self-completed(More)
OBJECTIVE To assess the health and economic burden of human papillomavirus (HPV)-related diseases (cervical cancer, cervical intraepithelial neoplasia (CIN) 1/2/3, and genital warts) in Singapore over a period of 25 years beginning in 2008. METHODS Incidence-based modeling was used to estimate the incidence cases and associated economic burden, with the(More)