Yu Kitago

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SORLA/SORL1 is a unique neuronal sorting receptor for the amyloid precursor protein that has been causally implicated in both sporadic and autosomal dominant familial forms of Alzheimer's disease (AD). Brain concentrations of SORLA are inversely correlated with amyloid-β (Aβ) in mouse models and AD patients, suggesting that increasing expression of this(More)
Reelin is a 3461-residue secreted glycoprotein that plays a critical role in brain development through its action on target neurons. Although it is known that functional reelin protein exists as multimer formed by interchain disulfide bond(s) as well as through non-covalent interactions, the chemical nature of the multimer assembly has been elusive. In the(More)
Synopsis A novel protein structure was solved by S-SAD using in-house chromium radiation. To reduce X-ray absorption of the cryo-buffer and cryoloop, a novel free crystal mounting technique was developed. Abstract A novel and easy crystal mounting technique was developed for the sulphur SAD method using chromium Kα radiation (2.29Å). Using this technique,(More)
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