Learn More
We have reported previously that prenatal bacterial lipopolysaccharide (LPS) exposure at the gestation window of vulnerability could consistently lead to dopamine (DA) neuron loss in the substantia nigra (SN). Thus, we suggested that prenatal LPS exposure might represent as a risk factor for the development of Parkinson's disease (PD). Here, we report that(More)
A new type of inhibitor of tubulin polymerization was discovered on the basis of the combretastatin molecular skeleton. The lead compounds in this series, compounds 6 and 7, strongly inhibited tubulin polymerization in vitro and significantly arrested cells at the G(2)/M phase. Compounds 6 and 7 yielded 50- to 100-fold lower IC(50) values than did(More)
—This paper presents a dimmable light-emitting diode (LED) driver with adaptive feedback control for low-power lighting applications. An improved pulsewidth modulation dimming technique is studied for regulating the LED current and brightness. Under universal input voltage operation, high efficiency and high power factor can be achieved by a coupled(More)
—A high-efficiency digital-controlled interleaved dc–dc converter is designed and implemented to provide a regulated high voltage output for high-power proton-exchange-membrane fuel-cell applications. Ripple cancellation on input current and output voltage can be achieved by the studied interleaved dc–dc power conversion technique to reduce hysteresis(More)