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We have reported previously that prenatal bacterial lipopolysaccharide (LPS) exposure at the gestation window of vulnerability could consistently lead to dopamine (DA) neuron loss in the substantia nigra (SN). Thus, we suggested that prenatal LPS exposure might represent as a risk factor for the development of Parkinson's disease (PD). Here, we report that(More)
This paper presents a dimmable light-emitting diode (LED) driver with adaptive feedback control for low-power lighting applications. An improved pulsewidth modulation dimming technique is studied for regulating the LED current and brightness. Under universal input voltage operation, high efficiency and high power factor can be achieved by a coupled inductor(More)
Two bistable multivibrators based on the operational transresistance amplifier (OTRA) are presented. The first topology consists of only one OTRA and a positive feedback network. The second multivibrator utilises a single-pole double-throw (SPDT) switch along with a bias voltage source to shift the hysteresis loop into either the right-half-part or the(More)
A new type of inhibitor of tubulin polymerization was discovered on the basis of the combretastatin molecular skeleton. The lead compounds in this series, compounds 6 and 7, strongly inhibited tubulin polymerization in vitro and significantly arrested cells at the G(2)/M phase. Compounds 6 and 7 yielded 50- to 100-fold lower IC(50) values than did(More)
Aberration in DNA replication is a major cause to genome instability that is a hallmark of cancer cells. Cell division cycle 6 (Cdc6) and c-Myc have a critical role in the initiation of DNA replication. However, whether their interaction induces epithelial-mesenchymal transition (EMT) and promotes tumorigenesis in in vivo animal model remains unclear. Since(More)