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Colorectal cancer (CRC) is the most frequently diagnosed cancer around the world, causing about 700,000 deaths every year. It is clear now that a small fraction of CRC, named colorectal cancer stem cells (CSCs) exhibiting self-renewal and extensive proliferative activities, are hard to be eradicated. Unfortunately, highly specific biomarkers for colorectal(More)
Helicobacter pylori (H. pylori) is a species of bacteria that can colonize the human stomach mucosa. It is closely associated with gastric diseases such as ulcer and inflammation. Recently, some H. pylori strains were found to express resistance to a family of antibiotics known as quinolones due to single-point mutations. Although traditional polymerase(More)
Helicobacter pylori (H. pylori) is a bacterium which can colonize the stomach mucosa and therefore play a crucial role in gastric diseases. Triple therapy treatment consisting of two antibiotics and a proton pump inhibitor has been routinely taken to eradicate H. pylori. Recently, some point mutations were found in gyrase genes against Quinolones. The(More)
Affinity reagents recognizing biomarkers specifically are essential components of clinical diagnostics and target therapeutics. However, conventional methods for screening of these reagents often have drawbacks such as large reagent consumption, the labor-intensive or time-consuming procedures, and the involvement of bulky or expensive equipment.(More)
Ovarian cancer has been one of the leading causes of death for women. However, it is still very challenging for its early diagnosis. The tedious conventional methods for screening specific biomarkers need at least two weeks or more. It was reported that cancer-specific oligopeptides could be screened from a phage display library. In this study, a new(More)
Reagents binding specifically to target molecules are essential tools for clinical diagnosis and targeted therapy. Screening of target cell-surface specific affinity reagents with bench-top methods has some drawbacks, including time-consuming, labor-intensive and requirement of large-scale instrument. Microfluidic platforms may overcome these drawbacks(More)
Ovarian cancer is one of the leading causes of female mortality worldwide. Unfortunately, there are currently few high-specificity candidate oligopeptide targeting agents that can be used for early diagnosis of this cancer. It has been suggested that cancer-specific oligopeptides could be screened from a phage display library. However, conventional methods(More)
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