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Understanding the structural organization of organs and organisms at the cellular level is a fundamental challenge in biology. This task has been approached by reconstructing three-dimensional structure from images taken from serially sectioned tissues, which is not only labor-intensive and time-consuming but also error-prone. Recent advances in tissue(More)
A 49-year-old man was presented for evaluation of a painless mass on his right posterior neck. The mass had gradually enlarged for a 25-year period without inflammation or rupture. On physical examination, a round, nontender, soft-tissue mass, 8 cm in diameter, was noted on the right posterior neck. The neck is a common site of epidermoid cysts, but a mass(More)
Transplantation and drug discovery programs for liver diseases are hampered by the shortage of donor tissue. While recent studies have shown that hepatic cells can be derived from human embryonic stem cells (hESCs), few cases have shown selective enrichment of hESC-derived hepatocytes and their integration into host liver tissues. Here we demonstrate that(More)
Highly homogeneous and functional stem cell-derived hepatocyte-like cells (HLCs) are considered a promising option in the cell-based therapy of liver disease and the development of effective in vitro toxicity screening tools. However, the purity of cells and expression and/or activity of drug metabolizing enzymes in stem cell-derived HLCs are usually too(More)
Smart bimetallic core@shell nanoparticles were fabricated based on gold nanoparticles (AuNPs) decorated with pH-sensitive polymer shell. Concretely, AuNPs having poly(4-vinylpyridine) (P4VP) on the surface were first fabricated through surface-initiated atom transfer radical polymerization (SI-ATRP). Then, they were mixed with selected metal precursor(More)
In this study, sulfur-doped graphene (S-graphene) was synthesized by thermal treatment of exfoliated graphene under CS2 gas flow. Its electrocatalytic activity as a metal-free catalyst was evaluated and compared with other doped-graphenes and commercial platinum nanoparticles loaded on carbon black (Pt/C) catalysts for oxygen reduction reaction (ORR) in(More)
We developed plasmonic dye-sensitized solar cells (DSSCs) with tailor-designed Au-TiO₂ nanostructures integrated into the photoanode. Mutually antagonistic Au-TiO₂ core-shell structures supported on SiO₂ spheres (SiO₂@TiO₂@AuNP and SiO₂@AuNP@TiO₂) were prepared and incorporated as additives into the photoanodes of the DSSCs. The DSSCs employing the(More)
BACKGROUND Poststernotomy mediastinitis is a rare, but life-threatening complication, thus early diagnosis and proper management is essential for poststernotomy mediastinitis. The main treatment for mediastinitis is aggressive debridement. Several options exist for reconstruction of defects after debridement. The efficacy of immediate debridement and(More)