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OBJECTIVES To evaluate the benefit of using autofluorescence bronchoscopy (AFB) for the detection and localization of early invasive lung cancer. METHODS AFB and white light bronchoscopy (WLB) were performed on 198 cases of suspected lung cancer, and the relative sensitivity of WLB plus AFB compared with WLB alone. RESULTS Included 198 biopsy specimens,(More)
Regulatory T (Treg) cells are potent suppressors that maintain immune homeostasis. Accumulation of Treg can inhibit effective immune responses in cancer patients, leading to tumor development and progression. Despite direct cytotoxicity, several chemotherapeutic drugs have been reported to deplete Treg cells for better prognosis for cancer patients. Treg(More)
Two dibenzoxanthenium derivatives bearing a 3,4-diaminophenyl group, compounds 1a and 1b, have been prepared and evaluated as near-infrared probes for the detection of nitric oxide. Compound 1a gave a 3-fold emission enhancement towards nitric oxide at 681 nm, whereas compound 1b exhibited OFF-ON emission behavior towards nitric oxide, resulting in a(More)
A cyanobenzo[a]phenoxazine-based pH probe with pKa = 5.0 exhibits OFF-ON emission at 625-850 nm upon excitation at 600 nm in aqueous buffers. The in cellulo imaging experiments with HeLa cells indicate that the probe can serve as a lysosome-specific probe under red light excitation (633 nm) with near infrared emission (650-790 nm).
BACKGROUND The development of abnormal involuntary movements or dyskinesia is a serious complication of L-3,4-dihydroxyphenylalanine (L-DOPA) therapy for Parkinson's disease (PD). OBJECTIVE To evaluate the correlation between dopamine transporter (DAT) regulated by L-DOPA and the pathogenesis of dyskinesia in PD rats. METHODS Thirty rats were used to(More)
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