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Endothelium‐mediated control of vascular tone: COX‐1 and COX‐2 products
Since in most cases, the activation of TP receptors is the common downstream effector, selective antagonists of this receptor should curtail endothelial dysfunction and be of therapeutic interest in the treatment of cardiovascular disorders. Expand
Activation of TRPV1 by dietary capsaicin improves endothelium-dependent vasorelaxation and prevents hypertension.
It is reported that chronic TRPV1 activation by dietary capsaicin increases the phosphorylation of protein kinase A and eNOS and thus production of nitric oxide in endothelial cells, which is calcium dependent, and may represent a promising target for therapeutic intervention of hypertension. Expand
Visceral Periadventitial Adipose Tissue Regulates Arterial Tone of Mesenteric Arteries
It is suggested that visceral periadventitial adipose tissue controls mesenteric arterial tone by inducing vasorelaxation via Kv channel activation in vascular smooth muscle cells. Expand
Calcium and reactive oxygen species increase in endothelial cells in response to releasers of endothelium‐derived contracting factor
Whether or not the intracellular concentration of calcium and reactive oxygen species (ROS) increase in endothelial cells of the rat thoracic aorta in response to releasers of endothelium‐derived contracting factor (EDCF) and if so, whether or not a difference exists between spontaneously hypertensive (SHR) and normotensive (WKY) rats. Expand
Systemic peripheral artery relaxation by KCNQ channel openers and hydrogen sulfide
It is suggested that KCNQ channel opening is a powerful mechanism to produce vasorelaxation of systemic arteries in rats and mice and play a major role in the paracrine control of vascular tone by perivascular adipose tissue, which is at least in part mediated or modulated by H2S. Expand
Adiponectin is a novel humoral vasodilator.
Adiponectin is a novel humoral vasodilator that relaxes aortic and mesenteric rings by opening K(v) channels in rat arteries and plays a role in the paracrine control of vascular tone by perivascular adipose tissue. Expand
Apelin modulates aortic vascular tone via endothelial nitric oxide synthase phosphorylation pathway in diabetic mice.
Apelin treatment modulates the abnormal aortic vascular tone in response to Ang II and acetylcholine by potentiating phosphorylation of Akt and eNOS in diabetic mice, suggesting that the apelin-APJ system might be an important regulator of vascular function in diabetes. Expand
Effect of phytosterols and their oxidation products on lipoprotein profiles and vascular function in hamster fed a high cholesterol diet.
It was concluded that Si and St not SiOP and StOP were beneficial in improving lipoprotein profile and aortic function and anti-atherosclerotic. Expand
Cyclooxygenase-2–Derived Prostaglandin F2&agr; Mediates Endothelium-Dependent Contractions in the Aortae of Hamsters With Increased Impact During Aging
It is demonstrated that PGF2&agr;, derived from COX-2, is the most likely EDCF underlying endothelium-dependent, thromboxane–prostanoid receptor–mediated contractions to ACh in hamster aortae with an increased importance during aging and, possibly, a similar relevance in humans. Expand
Stability of tea theaflavins and catechins
Abstract Green tea catechins (GTC) and theaflavins (TF) possess a variety of biological activities. The present study focused on stability of GTC and TF in various solutions and drinks. It wasExpand