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Abnormal sphingolipid metabolism has been previously reported in Alzheimer's disease (AD). To extend these findings, several sphingolipids and sphingolipid hydrolases were analyzed in brain samples from AD patients and age-matched normal individuals. We found a pattern of elevated acid sphingomyelinase (ASM) and acid ceramidase (AC) expression in AD,(More)
Contexts, the pieces of information that capture the characteristics of computing environments, are often inconsistent in the dynamic and uncertain pervasive computing environments. Various schemes have been proposed to check context consistency for pervasive applications. However, existing schemes implicitly assume that the contexts being checked belong to(More)
Caching is an important technique to support pervasive Internet access. Cache consistency measures the deviation between the cached data and the source data. In mobile computing environments, especially with ad hoc networks, users are in great need of the flexibility in tuning their consistency requirements, in order to make tradeoffs between the specified(More)
Formal specification and runtime detection of temporal properties for pervasive context is one of the primary approaches to achieving context-awareness. Though temporal logics have been widely used in specification of temporal properties, they are faced with severe challenges in Pervasive Computing (PvC) scenarios. First, temporal logics are traditionally(More)
Context-awareness is an essential feature of pervasive applications, and runtime detection of contextual properties is one of the primary approaches to enabling context awareness. However, existing context-aware middleware does not provide sufficient support for detection of contextual properties in asynchronous environments. We argue that in asynchronous(More)
The nuclear factor-kappaB (NF-kappaB) signal transduction pathway regulates several vital cellular processes. During our studies of the glycoproteins involved in Alzheimer disease (AD), we found a significant increase of a 45-kDa protein band that was stained by lectin Maackia amurensis agglutinin (MAA). Mass spectrometry and Western blot analyses indicated(More)
BACKGROUND The dose of transcranial direct current stimulation (tDCS) is defined by electrode montage and current, while the resulting brain current flow is more complex and varies across individuals. The left dorsolateral pre-frontal cortex (lDLPFC) is a common target in neuropsychology and neuropsychiatry applications, with varied approaches used to(More)
Protein glycosylation modifies the processing of several key proteins involved in the molecular pathogenesis of Alzheimer's disease (AD). Aberrant glycosylation of tau and down-regulation of sialyltransferase in AD brain suggest a possible dysregulation of protein glycosylation that may play a role in AD. We therefore isolated major glycoproteins from AD(More)
Internetware is envisioned as a new software paradigm for resource integration and sharing in the open, dynamic and autonomous network environment. In this paper we discuss our visions and explorations of this new paradigm, with focus placed on the methodological perspective. A set of enabling techniques on flexible coordination of autonomous services,(More)
One of the major applications of wireless ad hoc networks is to extend the Internet coverage and support pervasive and efficient data dissemination and sharing. To reduce data access cost and delay, caching has been widely used as an important technique. The efficiency of data access in caching systems largely depends on the cost for maintaining cache(More)