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The development of routine techniques for the isolation and in vitro maintenance of conducting airway epithelial cells in a differentiated state provides an ideal model to study the factors involved in the regulation of the expression of mucociliary differentiation. Several key factors and conditions have been identified. These factors and conditions(More)
We demonstrate a high-speed multi-functional spectral-domain optical coherence tomography system, using a broadband light source centered at 1.3 μm and two InGaAs line scan cameras capable of acquiring individual axial scans in 24.4 μs, at a rate of 18,500 axial scans per second. Fundamental limitations on the accuracy of phase determination as functions of(More)
Gel-forming mucins are major contributors to the viscoelastic properties of mucus secretion. Currently, four gel-forming mucin genes have been identified: MUC2, MUC5AC, MUC5B, and MUC6. All these genes have five major cysteine-rich domains (four von Willebrand factor [vWF] C or D domains and one Cystine-knot [CT] domain) as their distinctive features, in(More)
Human mucin (MUC) 5B gene expression in human airway epithelium was studied in both tissue sections and cultures of tracheobronchial epithelial (TBE) cells. In situ hybridization demonstrated that MUC5B message was expressed mainly in the mucous cells of submucosal glands of normal human airway tissues. Nevertheless, an elevated MUC5B message level could be(More)
Since the discovery of carbon nanotubes in 1991 by Iijima, there has been great interest in creating long, continuous nanotubes for applications where their properties coupled with extended lengths will enable new technology developments. For example, ultralong nanotubes can be spun into fibres that are more than an order of magnitude stronger than any(More)
Microstructures and mechanical properties of equal-channel angular pressing (ECAP) processed and naturally aged ultrafine grained (UFG) and coarse grained (CG) 7075 Al alloys as well as their evolutions during annealing were investigated. After the same natural aging, the tensile yield strength, ultimate strength, and microhardness of the UFG samples were(More)
beta-Defensin is one of the major host defense shields produced by various tissues and organs against microbial infection. To date, four human beta-defensins (DEFBs) gene products that share a consensus six-cysteine motif have been discovered. The hidden Markov model (HMM) profile was constructed from the common features of those known beta-defensin(More)
Optical coherence tomography (OCT) and optical coherence microscopy (OCM) allow the acquisition of quantitative three-dimensional axial flow by estimating the Doppler shift caused by moving scatter-ers. Measuring the velocity of red blood cells is currently the principal application of these methods. In many biological tissues, blood flow is often(More)
Use of links to enhance page ranking has been widely studied. The underlying assumption is that links convey recommendations. Although this technique has been used successfully in global web search, it produces poor results for website search, because the majority of the links in a website are used to organize information and convey no recommendations. By(More)
The traditional supervised classifier for Text Categorization (TC) is learned from a set of hand-labeled documents. However, the task of manual data labeling is labor intensive and time consuming, especially for a complex TC task with hundreds or thousands of categories. To address this issue, many semi-supervised methods have been reported to use both(More)