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Jaridonin-induced G2/M phase arrest in human esophageal cancer cells is caused by reactive oxygen species-dependent Cdc2-tyr15 phosphorylation via ATM-Chk1/2-Cdc25C pathway.
Jaridonin, a novel diterpenoid from Isodon rubescens, has been shown previously to inhibit proliferation of esophageal squamous cancer cells (ESCC) through G2/M phase cell cycle arrest. However, theExpand
Chelerythrine chloride induces apoptosis in renal cancer HEK-293 and SW-839 cell lines
Previous studies have demonstrated that the benzo[c]phenanthridine alkaloid chelerythrine chloride (CC) has inhibitory effects on various tumors. However, the anticancer activity of CC and itsExpand
The role of mitochondrial tRNA variants in female breast cancer
Abstract Mitochondrial tRNA (Mt-tRNA) variants have been found to be involved in the carcinogenesis of breast cancer. These tRNAs, which played critical roles in mitochondrial protein synthesis, wereExpand
Induction of the mitochondria-mediated apoptosis in human esophageal cancer cells by DS2, a newly synthetic diterpenoid analog, is regulated by Bax and caused by generation of reactive oxygen species
Ent-kaurane diterpene compounds have attracted considerable attention in recent years due to its antitumor, antibacterial, and antiviral activities. However, the clinical development of naturalExpand
ALDH2*2 Allele is a Negative Risk Factor for Cerebral Infarction in Chinese Women
Unlike its reported role in the cardiovascular diseases, little information is available for mitochondrial aldehyde dehydrogenase 2 (ALDH2) in the cerebrovascular function. We investigated theExpand
Biogeography and Adaptive evolution of Streptomyces Strains from saline environments
The genus Streptomyces is a widespread genus within the phylum Actinobacteria and has been isolated from various environments worldwide. However, little is known about whether biogeography affectsExpand
Individuals having variant genotypes of cytochrome P450 2C19 are at increased risk of developing primary liver cancer in Han populations, without infection with the hepatitis virus
Recently, many researchers have reported that the genetic polymorphisms of CYP2C19 may account for the interpatient variability of the clinical course in cancers including primary liver cancer (PLC).Expand
A novel gradient LC-MS/MS method for simultaneous determination of trimebutine maleate and its two metabolites in human plasma
A simple and rapid chromatography-tandem mass (LC-MS/MS) method has been developed for simultaneous determination of trimebutine maleate (TM) and its two major metabolites N-didemethyltrimebutineExpand
The effects of gender, unhealthy lifestyle and ALDH2 mutations on patients diagnosed with coronary artery diseases
Background: The potential associations between gender, lifestyles (only smoking and drinking habits considered), ALDH2 genotypes and Coronary Artery Diseases (CAD) have been sparingly reported.Expand