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Modulation of Glucagon-like Peptide-1 (GLP-1) Potency by Endocannabinoid-like Lipids Represents a Novel Mode of Regulating GLP-1 Receptor Signaling*
Background: Glucagon-like peptide-1 receptors (GLP-1Rs) are expressed in many tissues that are accessed only by a basal circulating level of GLP-1. Results: GLP-1 potency is enhanced by specificExpand
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Isolation of Positive Modulator of Glucagon-like Peptide-1 Signaling from Trigonella foenum-graecum (Fenugreek) Seed*
Background: Fenugreek is an edible plant used to treat diabetes and other disorders. Results: We isolated a new structure in fenugreek that enhances glucagon-like peptide-1 (GLP-1) potency.Expand
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Zwitterionic Polymer Conjugated Glucagon-like Peptide-1 for Prolonged Glycemic Control.
Glucagon-like peptide-1 (GLP-1) is of particular interest for treating type 2 diabetes mellitus (T2DM) as it induces insulin secretion in a glucose-dependent fashion and has the potential toExpand
Fenugreek Compound (N55) Lowers Plasma Glucose through the Enhancement of Response of Physiological Glucagon-like peptide-1
Glucagon-like peptide-1 (GLP-1) receptor (GLP-1R) analogues are approved for treating type 2 diabetes, but are known to activate GLP-1R signaling globally and constitutively. Active compound N55,Expand