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Association of TMPRSS6 polymorphisms with ferritin, hemoglobin, and type 2 diabetes risk in a Chinese Han population.
BACKGROUND Transmembrane protease serine 6 (TMPRSS6) regulates iron homeostasis by inhibiting the expression of hepcidin. Multiple common variants in TMPRSS6 were significantly associated with serumExpand
TMPRSS6, but not TF, TFR2 or BMP2 variants are associated with increased risk of iron-deficiency anemia.
A variety of conditions lead to anemia, which affects one-quarter of the world's population. Previous genome-wide association studies revealed a number of genetic polymorphisms significantlyExpand
TMPRSS 6 , but not TF , TFR 2 or BMP 2 variants are associated with increased risk of iron-deficiency anemia
Group of Bio-Metal Metabolism, Key Laboratory of Nutrition and Metabolism, Shanghai Key Laboratory of Pediatric Gastroenterology and Nutrition, Institute for Nutritional Sciences, Shanghai InstitutesExpand
Identification of hereditary hemochromatosis pedigrees and a novel SLC40A1 mutation in Chinese population.
  • P. An, Li Jiang, +8 authors F. Wang
  • Biology, Medicine
  • Blood cells, molecules & diseases
  • 11 January 2017
Screening identifies the Chinese medicinal plant Caulis Spatholobi as an effective HAMP expression inhibitor.
Hepcidin, the pivotal regulator of iron metabolism, plays a critical role in multiple diseases including anemia of chronic disease and hemochromatosis. Recent studies have focused on identifyingExpand