Yu. G. Plyashkevich

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The attention of research workers studying the molecular mechanisms of formation of anxiety states has recently been drawn to 8-carboline derivatives. It has been shown that several 8-carboline-3-carboxylates possess marked anxiogenic properties and that their pharmacological activity is mediated through benzodiazepine receptors (BDR) [4]. The existence of(More)
The acetylchol ine (ACh) r e c e p t o r s y s t e m s of mol luscan ganglia differ widely in the i r sens i t iv i ty to chol iner gic compounds. As well as t radi t ional synapses with Nnicotine" specif ic i ty , and blocked by ~-bungarotoxin , n icot ine, and tubocurar ine [7, 13], mol luscan neurons a lso contain synapses insensi t ive to(More)
The isolation and study of endogenous regulators of emotional states is an important theoretical and practical problem. The evident functional complexity of the emotional system, and the multiplicity and diversity of feedback in it make research in this direction an attractive but difficult process. Much progress in this direction has been achieved by Costa(More)
There is now adequate experimental data to show that guanylic nucleotides can either modulate binding of ligands with receptors [8] or participate directly in the regulation of biochemical processes of an efferent cell in response to the action of mediators [6]. These effects are observed for a number of hormone receptors, muscarinic acetylcholine(More)
The effects of benzodiazepine receptor agonist, diazepam, and inverse agonist, FG 7142, were examined. Strong antagonism between FG 7142 (10 mg/kg) and diazepam (1 mg/kg) activity was revealed in the open field test. On the other hand, both FG 7142 and diazepam inhibited isolation-induced intraspecies aggressive behaviour of rats. FG 7142 also reduced(More)
We studied in vitro effects of four 1,2,3,4-tetrahydroimidazo[4,5-c]-pyridine derivatives formed in the reaction of the corresponding aldehydes with histidine on the rate of ethanol oxidation by alcohol dehydrogenase isoforms from human liver. None of test compounds inhibited ethanol oxidation by these enzymes. Some of them increased alcohol dehydrogenase(More)
Individual sensitivity of organisms to drugs modifying the functional properties of systems controlling the level of emotional reactivity is an extremely urgent problem. The action of anxiety-inducing agents on learning has been inadequately studied [2], and individual differences in this matter remain virtually unstudied. Accordingly the comparative study(More)
We studied immediate and delayed effects of intraventricular injection of 1,2-epoxypropyltrimethylammonium chloride on behavioral reactions in rats. Apomorphine-induced yawning increased and orientation and exploratory activity was improved 144 h postinjection, which indicates activation of the brain dopaminergic system during this period.