Yu. E. Vitorgan

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The dynamics of redistribution of the isozyme spectrum of lactate and malate dehydrogenases in rat embryonic fibroblasts (REF) in contact with type 12 human adenovirus was studied and compared with the dynamics of changes in the fine structure of the mitochondria of the same cell models. The action of the oncogenic virus was shown to produce changes in the(More)
Hexokinase (EC 2.7.1.1) activity was studied in the soluble nuclear fraction and cytoplasm of rat embryonic fibroblasts (primary cultures) in the course of contact with infectious (A6) and oncogenic (A12) human adenoviruses. Higher activity of the enzyme was observed in the cytoplasmic fraction than in the nuclear in both normal and experimental samples.(More)
Kinetic studies of changes in isozymic forms of hexokinase, lactate and malate dehydrogenase and in total hexokinase activity during viral carcinogenesis were carried out. The test systems were rat embryo fibroblasts infected with an oncogenic variant of human adenovirus type 12 and an infectious adenovirus type 6, intact REF cultures in different stages of(More)
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