Learn More
Complex disease by definition results from the interplay of genetic and environmental factors. However, it is currently unclear how gene-environment interaction can best be used to locate complex disease susceptibility loci, particularly in the context of studies where between 1,000 and 1,000,000 markers are scanned for association with disease. We present(More)
The possibility of gene-environment interaction can be exploited to identify genetic variants associated with disease using a joint test of genetic main effect and gene-environment interaction. We consider how exposure misclassification and dependence between the true exposure E and the tested genetic variant G affect this joint test in absolute terms and(More)
An on-field colorimetric sensing strategy employing gold nanoparticles (AuNPs) and a paper-based analytical platform was investigated for mercury ion (Hg(2+)) detection at water sources. By utilizing thymine-Hg(2+)-thymine (T-Hg(2+)-T) coordination chemistry, label-free detection oligonucleotide sequences were attached to unmodified gold nanoparticles to(More)
Increasingly, designers seek feedback on their designs from crowd platforms such as social networks, Web forums, and paid task markets which demand different amounts of social capital, financial resources, and time. Yet it is unknown how the choice of crowd platform affects feedback generation. We conducted an online study where designers created initial(More)
Patients with head and neck cancer are treated through surgery, radiotherapy (RT), and chemotherapy (CT). Carotid artery damage and neurotoxicity were previously observed in these patients. This study estimated the dementia risk associated with different treatment modalities in a head and neck cancer population with long-term follow-up. Taiwan's National(More)
For locally advanced head and neck squamous cell carcinoma (HNSCC), therapeutic decisions depend on comorbidity or age. We estimated the treatment outcomes of patients with different Charlson comorbidity index (CCI) scores and ages to determine whether aggressive treatment improves survival.Data from the Taiwan National Health Insurance and cancer registry(More)
The use of induction chemotherapy (CT) is controversial. We compared the survival of head and neck cancer patients receiving docetaxel- or platinum-based induction CT before concomitant chemoradiotherapy (CCRT) with the survival of those receiving upfront CCRT alone. Data from the National Health Insurance and cancer registry databases in Taiwan were linked(More)
Feedback from diverse audiences can contain ambiguity and contradictions, making it difficult to interpret and act on. To promote deeper interpretation of feedback, we tested the effects of combining a reflection activity and reviewing external feedback for an iterative design task. Designers (N=90) created a design and revised it after a) performing a(More)
As demand for design education increases, instructors are struggling to provide timely, personalized feedback for student projects. Gathering feedback from classroom peers and external crowds offer scalable approaches, but there is little evidence of how they compare. We report on a study in which students (n=127) created early- and late-stage prototypes as(More)
Online crowd platforms (e.g. social networks, online communities, task markets) enable designers to gain insights from large audiences quickly and affordably. However, there is no guidance for designers to better allocate their social capital, time, and financial resources for acquiring feedback that meets their own needs. Also, feedback received online can(More)