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The aim of this study was to investigate whether diabetes mellitus (DM) affected breast cancer resistance protein (Bcrp) function and expression in rat brain. 5-week and 8-week diabetic rats were induced by streptozocin (STZ). Bcrp expression and function in brain cortex were assessed by western blot and measuring the brain-to-plasma concentration ratios of(More)
To investigate whether long-term exposure to four typical antiepileptic drugs (AEDs): phenobarbital (PB), phenytoin (PHT), carbamazepine (CBZ) and valproic acid (VPA) can increase P-glycoprotein (P-gp) level and function in primary cultured rat brain microvascular endothelial cells (rBMECs) in vitro, the rBMECs were incubated in culture medium containing(More)
Overexpression of P-glycoprotein may be involved in multidrug resistance of epilepsy, but the mechanisms are not clear. The aim of the studies was to investigate whether chronic exposure of antiepileptic drugs (AEDs) increased P-glycoprotein (P-gp) function and expression in brain of rats. Three drugs phenobarbital (PB), phenytion (PHT) and carbamazepine(More)
OBJECTIVE This study aimed to (i) explore the prevalence and levels (severity) of anxiety and depression in family caregivers (FCs) of patients newly diagnosed with advanced lung cancer (stage IIIb or IV) before first treatment, and (ii) identify the factors related to FCs' anxiety and depression. METHODS For this cross-sectional study, 106 patient-FC(More)
A low-power ultra-compact CMOS low-noise amplifier (LNA) in a shunt-resonating current-reused topology is presented. The common-source transistors are connected with a shunt-resonating inter-stage match network such that the bias current is shared to have low power consumption and RF signal is doubly amplified to have high gain and low noise figure. The(More)
These terms “functionality”, “usability” and “pleasurability” are being studied for many years. There are many standards or scales to evaluate, but there are fewer to discuss how to assess pleasurability. What's pleasurability? People are aware of the importance of living quality both materially and spiritually,(More)
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