Yu-Chia Chang

Publications40
h-index12
Citations309
Highly Influential Citations6
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Cluster analysis of cardiovascular and metabolic risk factors in women of reproductive age.
TLDR
Obesity was the major determinant of cardiometabolic disturbances in reproductive-aged women and hyperprolactinemia and premature ovarian failure were not associated with the risk of cardiovascular and metabolic diseases. Expand
Flexibilide Obtained from Cultured Soft Coral Has Anti-Neuroinflammatory and Analgesic Effects through the Upregulation of Spinal Transforming Growth Factor-β1 in Neuropathic Rats
TLDR
The results suggest that flexibilide may serve as a therapeutic agent for neuropathic pain and that spinal TGF-β1 may be involved in the anti-neuroinflammatory and analgesic effects of flexibILide. Expand
The Bioactive Extract of Pinnigorgia sp. Induces Apoptosis of Hepatic Stellate Cells via ROS-ERK/JNK-Caspase-3 Signaling
TLDR
It appears that Pin leads to apoptosis in HSC-T6 cells through ROS-mediated ERK/JNK signaling and caspase-3 activation and pinnigorgiol A serves as a bioactive compound of Pin and may exhibit therapeutic potential by clearance of HSCs. Expand
Marine-derived protein kinase inhibitors for neuroinflammatory diseases
TLDR
The previous studies from 1990 to 2017 in this review have shown that marine-derived protein kinase inhibitors have great potential to elicit anti-neuroinflammatory or neuroprotective responses in in vitro and in vivo models of neuroinflammatory diseases. Expand
PDGF-metronidazole-encapsulated nanofibrous functional layers on collagen membrane promote alveolar ridge regeneration
TLDR
The FGM with PDLLA-PDGF enhanced alveolar ridge regeneration in vivo showed high biocompatibility and facilitated wound healing compared with conventional membrane, and the design represents a beneficial modification, which may be easily adapted for future clinical use. Expand
1H NMR-Based Isolation of Anti-Inflammatory 9,11-Secosteroids from the Octocoral Sinularia leptoclados
TLDR
Among the above-mentioned isolates, compound 4 had the most pronounced effect in inhibiting elastase release and superoxide anion generation, with the IC50 values of 2.96 and 1.63 μM, respectively. Expand
Isolation of marine bacteria with antimicrobial activities from cultured and field-collected soft corals
TLDR
The results demonstrate that the marine bacteria from corals have great potential in the discovery of useful medical molecules. Expand
Chlorinated briarane diterpenoids from the sea whip gorgonian corals Junceella fragilis and Ellisella robusta (Ellisellidae).
TLDR
A new chlorinated briarane, fragilide J, has been isolated from the sea whip gorgonian coral Junceella fragilis, and the structure, including the absolute configuration of 3, was further confirmed by X-ray data analysis for the first time. Expand
Interaction between nicotine and MPTP/MPP+ in rat brain endothelial cells.
TLDR
Nicotine can inhibit in vitro cellular uptake and in vivo transfer of MPTP across the blood-brain barrier, which can be mediated by multiple pathways including OCT1. Expand
(-)-Hydroxylindestrenolide, a new sesquiterpenoid from a gorgonian coral Menella sp. (Plexauridae).
TLDR
Sesquiterpenoid 1 exhibited marginal cytotoxicity toward HL-60 and K562 leukemia tumor cells, and displayed a weak inhibitory effect on superoxide anion generation at a concentration of 10 µg/ml by human neutrophils. Expand
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