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Mutations in the human LIS1 gene cause the smooth brain disease classical lissencephaly. To understand the underlying mechanisms, we conducted in situ live cell imaging analysis of LIS1 function throughout the entire radial migration pathway. In utero electroporation of LIS1 small interference RNA and short hairpin dominant negative LIS1 and dynactin cDNAs(More)
Technical support contributes 17% of the total cost of ownership of today's desktop PCs [25]. An important element of technical support is troubleshooting miscon-figured applications. Misconfiguration troubleshooting is particularly challenging, because configuration information is shared and altered by multiple applications. In this paper, we present a(More)
Metastatic prostate cancer is treated with drugs that antagonize androgen action, but most patients progress to a more aggressive form of the disease called castration-resistant prostate cancer, driven by elevated expression of the androgen receptor. Here we characterize the diarylthiohydantoins RD162 and MDV3100, two compounds optimized from a screen for(More)
The development of dendritic spines is thought to be crucial for synaptic plasticity. Dendritic spines are retracted upon Eph receptor A4 (EphA4) activation, but the mechanisms that control this process are not well understood. Here we report an important function of cyclin-dependent kinase 5 (Cdk5) in EphA4-dependent spine retraction in mice. We found that(More)
We describe a new approach, called Strider, to Change and Configuration Management and Support (CCMS). Strider is a black-box approach: without relying on specifications, it uses state differencing to identify potential causes of differing program behaviors, uses state tracing to identify actual, run-time state dependencies, and uses statistical behavior(More)
NudE and NudEL are related proteins that interact with cytoplasmic dynein and LIS1. Their functional relationship and involvement in LIS1 and dynein regulation are not completely understood. We find that NudE and NudEL each localize to mitotic kinetochores before dynein, dynactin, ZW10, and LIS1 and exhibit additional temporal and spatial differences in(More)
Neurotrophins are key regulators of neuronal survival and differentiation during development. Activation of their cognate receptors, Trk receptors, a family of receptor tyrosine kinases (RTKs), is pivotal for mediating the downstream functions of neurotrophins. Recent studies reveal that cyclin-dependent kinase 5 (Cdk5), a serine/threonine kinase, may(More)
In this report we construct correction coefficients to obtain high-order trape-zoidal quadrature rules to evaluate 2-dimensional integrals with a logarithmic sin-gularity of the form J(v) = D v(x, y) ln(x 2 + y 2)dxdy, where the domain D is a square containing the point of singularity (0, 0) and v is a C ∞ function defined on the whole plane R 2. The(More)
Based on an architecture that allows to combine statistical machine translation (SMT) with rule-based machine translation (RBMT) in a multi-engine setup, we present new results that show that this type of system combination can actually increase the lexical coverage of the resulting hybrid system, at least as far as this can be measured via BLEU score.