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The development of dendritic spines is thought to be crucial for synaptic plasticity. Dendritic spines are retracted upon Eph receptor A4 (EphA4) activation, but the mechanisms that control this process are not well understood. Here we report an important function of cyclin-dependent kinase 5 (Cdk5) in EphA4-dependent spine retraction in mice. We found that(More)
Technical support contributes 17% of the total cost of ownership of today's desktop PCs [25]. An important element of technical support is troubleshooting miscon-figured applications. Misconfiguration troubleshooting is particularly challenging, because configuration information is shared and altered by multiple applications. In this paper, we present a(More)
Metastatic prostate cancer is treated with drugs that antagonize androgen action, but most patients progress to a more aggressive form of the disease called castration-resistant prostate cancer, driven by elevated expression of the androgen receptor. Here we characterize the diarylthiohydantoins RD162 and MDV3100, two compounds optimized from a screen for(More)
Cells must amplify external signals to orient and migrate in chemotactic gradient fields. We find that human neutrophils release adenosine triphosphate (ATP) from the leading edge of the cell surface to amplify chemotactic signals and direct cell orientation by feedback through P2Y2 nucleotide receptors. Neutrophils rapidly hydrolyze released ATP to(More)
We describe a new approach, called Strider, to Change and Configuration Management and Support (CCMS). Strider is a black-box approach: without relying on specifications, it uses state differencing to identify potential causes of differing program behaviors, uses state tracing to identify actual, run-time state dependencies, and uses statistical behavior(More)
Neurotrophins are key regulators of neuronal survival and differentiation during development. Activation of their cognate receptors, Trk receptors, a family of receptor tyrosine kinases (RTKs), is pivotal for mediating the downstream functions of neurotrophins. Recent studies reveal that cyclin-dependent kinase 5 (Cdk5), a serine/threonine kinase, may(More)
This paper presents a new spectral template-matching approach to countering shrew distributed denial-of-service (DDoS) attacks. These attacks are stealthy, periodic, pulsing, and low-rate in attack volume, very different from the flooding type of attacks. They are launched with high narrow spikes in very low frequency, periodically. Thus, shrew attacks may(More)
Geographic routing is of interest for sensor networks because a point-to-point primitive is an important building block for data-centric applications. While there is a significant body of work on geographic routing algorithms for two-dimensional (2D) networks, geographic routing for practical three-dimensional (3D) sensor networks is relatively unexplored.(More)
In this report we construct correction coefficients to obtain high-order trape-zoidal quadrature rules to evaluate 2-dimensional integrals with a logarithmic sin-gularity of the form J(v) = D v(x, y) ln(x 2 + y 2)dxdy, where the domain D is a square containing the point of singularity (0, 0) and v is a C ∞ function defined on the whole plane R 2. The(More)