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To investigate the effect of the small molecule, RepSox, on the expression of developmentally important genes and the pre-implantation development of rhesus monkey–pig interspecies somatic cell nuclear transfer (iSCNT) embryos. Rhesus monkey cells expressing the monomeric red fluorescent protein 1 which have a normal (42) chromosome complement, were used as(More)
To examine the effect of PCI-24781 (abexinostat) on the blastocyst formation rate in pig somatic cell nuclear transferred (SCNT) embryos and acetylation levels of the histone H3 lysine 9 and histone H4 lysine 12. Treatment with 0.5 nM PCI-24781 for 6 h significantly improved the development of cloned embryos, in comparison to the control group (25.3 vs.(More)
Pulmonary nodule is a common lung disease, which can be prone to misdiagnosis and missed diagnosis. With the extensive application of CT technology, doctor's diagnostic efficiency has been greatly improved. However, the amount of CT image data is relatively large. Radiologists have to take a lot of time to read these images, and easy to overlook some minor(More)
The aim of this study was to investigate the developmental competence of oocytes parthenogenetically activated by an electric pulse (EP) and treated with anisomycin and to determine whether this method is applicable to somatic cell nuclear transfer (SCNT). Embryos derived from porcine oocytes parthenogenetically activated by an EP and treatment with 0.01(More)
With the development of new sequencing technology, the entire N6-methyl-adenosine (m(6)A) RNA methylome can now be unbiased profiled with methylated RNA immune-precipitation sequencing technique (MeRIP-Seq), making it possible to detect differential methylation states of RNA between two conditions, for example, between normal and cancerous tissue. However,(More)
Recent development of MeRIP-Seq enabled the global unbiased profiling of transcriptome-wide N6-Adenosine. With this technique, it is now possible to detect the RNA methylation sites under a specific condition or the differential methylation sites between two experimental conditions. However, as an affinity-based approach, MeRIP-Seq has yet provided(More)
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