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Journals and Conferences
The biological activity of a series of new amino derivatives of dehydroabietic acid has been studied. 12-N,N-Diethylaminoacetyl-8,11,13-abietatrien-18-oate hydrochloride produces a calming effect, shows pronounced anxiolytic activity, and exhibits antipyretic action comparable with that of the reference drug (analgin).
The biological activity of several lupane and oleanane β-enaminoketones was studied. Comparative analysis of leukocyte reactions showed that both groups of triterpene derivatives had high biological activity on chronic administration and that their immunosuppressive activity resulted from toxic effects on lymphocytes.
2-Alkylaminomethylene-19β,28-epoxyolean-3-ones were obtained by interaction of 2-hydroxymethylene-19β,28-epoxyolean-3-one with aliphatic amines. Some of the resulting substances exhibit immunotropic activity.
The immunotropic effect of the 2,3-seco derivatives of allobetulon, betulonic acid, and the methyl ester of betulonic acid were studied. It was found that the highest activity is shown by compounds with an oleanane fragment. The presence of a free C28-carboxyl group enhances the activity of lupane 2,3-seco derivatives. A significant contribution to the… (More)
Substituted amides and hydrazides of dialkylaminoacetic and arylaminoacetic acids are peptidomimetics and exhibit biological activity [1, 2]. Recently , we described the synthesis and some biological effects of N-[2-( p-hydroxyphenyl)-1,1-dialkylethyl]amides of some carboxylic acids. In continuation of investigations in this direction, we report on the… (More)
As is known, the ulcerogenic properties of nonsteroidal antiinflammatory drugs is a factor limiting their use in clinics. It was established that the side effects can sometimes be reduced by attaching a pharmacophore fragment to a natural amino acid residue. In this context, we have synthesized ibuprofen amides (I – III) by the condensation of ibuprofen… (More)
Nonsteroidal anti-inflammatory drugs and non-narcotic analgesics are widely used to treat various inflammatory diseases of infectious and noninfectious nature . The development of new drugs based on terpenophenols, which have a unique set of pharmacological properties , is highly promising. The literature teaches that phenols with a bicyclic isobornyl… (More)
A series of 3-spiro[adamantane-2,3′-isoquinolines] were synthesized. Their neurotropic activity and cytotoxicity were evaluated. Two compounds with anxiolytic activity were found, one of which showed antitumor activity in vitro.
Amides of four types were synthesized derived from 2,3-seco-18αH-oleanane and 2,3-secolupane mono- and dicarboxylic acids. The spectrum of diamide derivatives was expanded with C3-C3′ and C28-C28′ biscondensed amides with two A-secotriterpene backbones obtained by the interaction of monocarboxylic A-seco acids with lysine. Among the synthesized monoand… (More)
New isoquinolin-1-one derivatives were prepared. These compounds had low toxicity and marked influences on motor and investigative activity in mice. Compound 3,3-pentamethylene-3,4-dihydroisoquinolin-1-one had central analgesic activity.