Yu. B. Smirnova

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The reverse transcriptase inhibitors (RTI) azidothymidine and carbovir can block telomerase function in various cells, whereas dideoxycytidine does not exhibit such activity. RTI induce senescence in 3T3 Swiss, NIH 3T3 cell cultures and in the clones of immortal spontaneously transformed mouse fibroblasts. The RTI-induced senescence of L6 rat myoblasts in(More)
The distribution of two variants of MDG4 (gypsy) was analyzed in severalDrosophila melanogasterstrains. Southern blot hybridization revealed the inactive variant of MDG4 in all strains examined and active MDG4 only in some of them. Most of the strains harboring the active MDG4 variant were recently isolated from natural populations. It is of interest that(More)
Allele and genotype frequencies of the HindIII polymorphism of the lipoprotein lipase (LPL) gene were studied in patients with myocardial infarction (MI) and stable angina of effort (SAE), including long-lived people (over 90). The polymorphism proved to be associated with MI and with the life span, genotype H+/H+ being predisposing to MI and allele H–(More)
Two types of spontaneously transformed cells appear in the culture of senescent mouse embryonic fibroblasts. The first type are cells with restricted proliferative potential (up to 30 population doublings); the other type are immortalized cells. Cells of the first type, unlike those of the second, have no telomerase activity and undergo two rounds of(More)
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