Yu. A. Popov

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A hybrid plasmid pUB110PA-1, which functions stably in cells of Bacillus strains and contains the gene for synthesis of the protective antigen of the anthrax microbe, Bacillus anthracis, has been constructed. Recombinant strains were obtained that surpass anthrax Bacillus cultures in the secretory synthesis of the protective antigen. Their immunologic(More)
An asporogenic recombinant strain Bacillus anthracis 55ΔTPA-1(Spo−) producing anthrax protective antigen (PA) was obtained. The strain contains structural gene pag as a part of a hybrid replicon pUB110PA-1 and lacks determinants encoding the synthesis of main factors of anthrax pathogenicity. The level of PA production by asporogenic genetically engineered(More)
Genomic fingerprinting analysis of strains of the basic subspecies of plague causative agent extracted from different types of hotbeds in the Russian Federation and neighboring countries was performed. This analysis has enabled us to demonstrate their significant genetic polymorphism, as well as the similarity of their phenotypic characteristics. Strains of(More)
Comparative analysis of nucleotide sequences in genes that encode synthesis of methionine metabolism enzymes in the Bacillus anthracis strains and closely related bacterial species was conducted. A 42-bp deletion in the hom2 gene, which determines homoserine dehydrogenase, was found in all tested strains of the anthrax microbe. No mutation in the hom2 gene(More)
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