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The effects of bilateral olfactory bulbectomy on serotonergic 5-HT2 and 5-HT1A receptor binding were studied in the frontal cortex (FC), limbic structures (LS), including the hippocampus, amygdala, olfactory tubercule, and piriform cortex, and hypothalamus (HTH) in mice. Bulbectomy resulted in the increase of Bmax for [3H]spiperone binding with 5-HT2(More)
The behavioral effects of bulbectomy and subsequent antidepressant treatment in two mice strains were compared on measures of open field behavior and passive and active avoidance 2 and 4 weeks after surgery. After bulbectomy, both strains displayed elevated locomotion in open field, corrected by antidepressants. Enhanced rearing was decreased by(More)
Bulbectomy has been previously shown to produce the specific antidepressant-sensitive syndrome in C57Bl/6j, but not DBA/2j mice. The present study examined the effect of the depression on voluntary alcohol consumption. Alcohol consumption and alcohol preference (% of alcohol solution in total liquid) in a free-choice, two-bottle situation was measured in(More)
The primary skin-muscular fibroblasts were isolated from 15-day-old embryos of SHR rats with the SPF status (the nursery of Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry (Pushchino Branch), Russian Academy of Sciences, Pushchino). The suspension of fibroblasts was placed in tissue culture flasks impermeable to UV-A and orange–red light (ORL).(More)
pp. 412-449. 7. M. N. Rusalova, Experimental Investigation of Human Emotional Reactions [in Russian], Moscow (1979), pp. 45-66. 8. P. V. Simonov and N. V. Frolov, Problems in Physiology and Pathology of Higher Nervous Activity [in Russian], No. 4, Leningrad (1970), pp. 149-159. 9. P. V. Simonov, The Emotional Brain, Plenum Press, New York-London (1986). i0.(More)
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