Youxin Zhang

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Fcgamma Receptor (FcR)-mediated phagocytosis by macrophages requires phosphatidylinositol 3-kinase (PI3K) and activation of the Rho-family GTPases Cdc42 and Rac1. Cdc42 is activated at the advancing edge of the phagocytic cup, where actin is concentrated, and is deactivated at the base of the cup. The timing of 3' phosphoinositide (3'PI) concentration(More)
During Fcγ receptor (FcR)-mediated phagocytosis by macrophages, cytoplasm advances over IgG-coated particles by the sequential ligation of FcR in plasma membranes. If FcR signaling was strictly autonomous, then the signals generated during phagocytosis should be proportional to the number of ligated receptors. By measuring FcR-dependent responses to beads(More)
Deactivating strategies, including preemptive and postemptive strategies, are effective methods used by avoidant adults to regulate emotional processing. In the present study, we examined the mechanisms of preemptive and postemptive strategies used by highly avoidant participants to defend against emotional faces. Event-related potentials were recorded(More)
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