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CXCL10 Is Critical for the Progression and Maintenance of Depigmentation in a Mouse Model of Vitiligo
TLDR
Surprisingly, CXCL10 neutralization in mice with established, widespread depigmentation induces reversal of disease, evidenced by repigmentation, which identifies a critical role for CxCL10 in both the progression and maintenance of vitiligo and thereby support inhibiting C XCL10 as a targeted treatment strategy.
Aberrant Expression of Collagen Triple Helix Repeat Containing 1 in Human Solid Cancers
TLDR
Aberrant expression of CTHRC1 is widely present in human solid cancers and seems to be associated with cancer tissue invasion and metastasis.
Expression of the UNC-5 guidance receptor in the touch neurons of C. elegans steers their axons dorsally
TLDR
The results support previous evidence that UNC-5 and UNC-6 play instructive rules in guiding growth cone migrations on the epidermis in C. elegans and indicate that pioneering growth cones, which normally migrate in different directions, may use equivalent intracellular signalling mechanisms for guidance.
Genome-wide association study for vitiligo identifies susceptibility loci at 6q27 and the MHC
TLDR
The study provides new insights into the genetic basis of vitiligo and identified one previously undescribed risk locus at 6q27, which contains three genes: RNASET2, FGFR1OP and CCR6.
Increased expression of integrin-linked kinase is correlated with melanoma progression and poor patient survival.
TLDR
ILK expression increases dramatically with melanoma invasion and progression and is inversely correlated with patient survival, and it is shown that strong ILK expression is significantly associated with melanomas thickness.
Genetic Variation of Promoter Sequence Modulates XBP1 Expression and Genetic Risk for Vitiligo
TLDR
This study has demonstrated that the transcriptional modulation of XBP1 expression by a germ-line regulatory polymorphism has an impact on the development of vitiligo.
Deficiency of SATB1 expression in Sezary cells causes apoptosis resistance by regulating FasL/CD95L transcription.
TLDR
It was found that Sézary cells are deficient in the expression of special AT-rich region binding protein 1 (SATB1), a key regulator of T-cell development and maturation, and restoration of SATB1 expression may represent a potential molecular targeted therapy for SS.
Elucidating the role of interleukin-17F in cutaneous T-cell lymphoma.
TLDR
It is shown that a set of malignant T-cell lines established from patients with cutaneous T- cell lymphoma spontaneously secrete IL-17F and that inhibitors of Janus kinases and Signal transducer and activator of transcription 3 are able to block that secretion.
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