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Sequential reassortments underlie diverse influenza H7N9 genotypes in China.
Initial genetic characterizations have suggested that the influenza A (H7N9) viruses responsible for the current outbreak in China are novel reassortants. However, little is known about the pathways… Expand
Cell membrane proteins with high N-glycosylation, high expression and multiple interaction partners are preferred by mammalian viruses as receptors
- Zheng Zhang, Zhaozhong Zhu, +11 authors Yousong Peng
- Medicine, Computer Science
- 9 August 2018
Motivation: Receptor mediated entry is the first step for viral infection. However, the question of how viruses select receptors remains unanswered. Results: Here, by manually curating a high‐quality… Expand
Mapping of H3N2 influenza antigenic evolution in China reveals a strategy for vaccine strain recommendation.
One of the primary efforts in influenza vaccine strain recommendation is to monitor through gene sequencing the viral surface protein haemagglutinin (HA) variants that lead to viral antigenic… Expand
Antigenic Patterns and Evolution of the Human Influenza A (H1N1) Virus
The influenza A (H1N1) virus causes seasonal epidemics that result in severe illnesses and deaths almost every year. A deep understanding of the antigenic patterns and evolution of human influenza A… Expand
Inferring the antigenic epitopes for highly pathogenic avian influenza H5N1 viruses.
The evasion of influenza virus from host immune surveillance is mainly mediated through its surface protein hemagglutinin (HA), the main component of influenza vaccine. Thus, identification of… Expand
Antigenic variation of the human influenza A (H3N2) virus during the 2014–2015 winter season
The human influenza A (H3N2) virus dominated the 2014–2015 winter season in many countries and caused massive morbidity and mortality because of its antigenic variation. So far, very little is known… Expand
A comprehensive surveillance of adamantane resistance among human influenza A virus isolated from mainland China between 1956 and 2009.
BACKGROUND Adamantane-derived drugs have been used for treatment and prophylaxis of influenza A virus infection for many years worldwide. Rapid surveillance of antiviral drug resistance is important… Expand
Correlation of Influenza Virus Excess Mortality with Antigenic Variation: Application to Rapid Estimation of Influenza Mortality Burden
The variants of human influenza virus have caused, and continue to cause, substantial morbidity and mortality. Timely and accurate assessment of their impact on human death is invaluable for… Expand
A universal computational model for predicting antigenic variants of influenza A virus based on conserved antigenic structures
Rapid determination of the antigenicity of influenza A virus could help identify the antigenic variants in time. Currently, there is a lack of computational models for predicting antigenic variants… Expand
Continual Antigenic Diversification in China Leads to Global Antigenic Complexity of Avian Influenza H5N1 Viruses
The highly pathogenic avian influenza (HPAI) H5N1 virus poses a significant potential threat to human society due to its wide spread and rapid evolution. In this study, we present a comprehensive… Expand