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PURPOSE To assess the incremental value of diffusion-weighted (DW) magnetic resonance (MR) imaging over T2-weighted MR imaging at 3 T for prostate cancer detection and to investigate the use of the apparent diffusion coefficient (ADC) to characterize tumor aggressiveness, with whole-mount step-section pathologic analysis as the reference standard. (More)
PURPOSE To evaluate the relationship between prostate cancer aggressiveness and histogram-derived apparent diffusion coefficient (ADC) parameters obtained from whole-lesion assessment of diffusion-weighted magnetic resonance (MR) imaging of the prostate and to determine which ADC metric may help best differentiate low-grade from intermediate- or high-grade(More)
PURPOSE To retrospectively measure the mean apparent diffusion coefficient (ADC) with diffusion-weighted magnetic resonance (MR) imaging and the mean metabolic ratio (MET) with three-dimensional (3D) hydrogen 1 ((1)H) MR spectroscopic imaging in regions of interest (ROIs) drawn over benign and malignant peripheral zone (PZ) prostatic tissue and to assess(More)
OBJECTIVE To investigate the repeatability of the quantitative magnetic resonance imaging (MRI) metric (apparent diffusion coefficient [ADC]) derived from reduced field-of-view diffusion-weighted (rFOV DWI) on thyroid glands in a clinical setting. MATERIALS AND METHODS Ten healthy human volunteers were enrolled in MRI studies performed on a 3-T MRI(More)
OBJECTIVE The purpose of this study was to differentiate clear cell renal cell carcinoma (RCC) from other common renal cortical tumors by use of DWI. MATERIALS AND METHODS The study included 117 patients (mean age, 60 years) with 122 histopathologically confirmed renal cortical tumors who underwent 1.5-T MRI that included DWI before they underwent(More)
BACKGROUND Initial management recommendations of papillary thyroid carcinoma (PTC) are very dependent on preoperative studies designed to evaluate the presence of PTC with aggressive features. The purpose of this study was to evaluate whether diffusion-weighted magnetic resonance imaging (DW-MRI) before surgery can be used as a tool to stratify tumor(More)
OBJECTIVE To assess the effect of histopathological lesion characteristics on the sensitivity of magnetic resonance imaging (MRI) for per-lesion identification of extracapsular extension (ECE) of prostate cancer. PATIENTS AND METHODS The study included 176 patients (median age 58.9 years, range 38-77) who underwent endorectal MRI before radical(More)
PURPOSE To retrospectively investigate whether the signal intensity (SI) of prostate cancer on T2-weighted magnetic resonance (MR) images correlates with the Gleason grade at whole-mount step-section pathologic evaluation after radical prostatectomy. MATERIALS AND METHODS The institutional review board approved and issued a waiver of informed consent for(More)
PURPOSE To retrospectively determine the accuracy of diffusion-weighted (DW) magnetic resonance (MR) imaging for identifying cancer in the prostate peripheral zone (PZ) and to assess the accuracy of tumor volume measurements made with T2-weighted imaging and combined T2-weighted and DW MR imaging by using surgical pathologic examination as the reference(More)
PURPOSE This study aimed to compare the intraclass correlation coefficients of parameters estimated with stretched exponential and biexponential diffusion models of in vivo diffusion-weighted magnetic resonance imaging (MRI) of the prostate. METHODS After the institutional review board issued a waiver of informed consent for this Health Insurance(More)