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Deep Vertebrate Roots for Mammalian Zinc Finger Transcription Factor Subfamilies
TLDR
V vertebrate “DNA binding orthologs” were searched for by mining ZNF loci from eight sequenced genomes and then aligning the patterns of DNA-binding amino acids, or “fingerprints,” extracted from the encoded ZNF motifs, finding hundreds of lineage-specific genes in each species and also hundreds of orthologous groups.
Epigenetic Regulators in the Development, Maintenance, and Therapeutic Targeting of Acute Myeloid Leukemia
TLDR
The importance of epigenetic dysregulation to acute myeloid leukemia (AML) pathophysiology has become increasingly apparent and emerging epigenome-based therapies for the treatment of AML in the clinic are discussed.
Function and Evolution of C2H2 Zinc Finger Arrays.
TLDR
This chapter reviews the properties and their remarkable evolutionary history of eukaryotic KZNF TF proteins, with special focus on large families that dominate the TF landscapes in different metazoan species.
Novel DNA ligase with broad nucleotide cofactor specificity from the hyperthermophilic crenarchaeon Sulfophobococcus zilligii: influence of ancestral DNA ligase on cofactor utilization.
TLDR
It is contended that DNA ligase evolution likely started from crenarchaeotal DNA ligases and diverged to eukaryal DNA ligasing and euryarchaeOTAL DNA ligased, and the NAD(+)-utilizing property of some eury archaealDNA ligases may have successfully differentiated to bacterial NAD( +)-dependent DNA ligas.
Characterization of cold-active uracil-DNA glycosylase from Bacillus sp. HJ171 and its use for contamination control in PCR
TLDR
These heat-labile characteristics enabled Bsp HJ171 UDG to control carry-over contamination in the polymerase chain reaction product (PCR) without losing the PCR product.
Unique Substrate Spectrum and PCR Application of Nanoarchaeum equitans Family B DNA Polymerase
TLDR
The results suggest that Neq DNA polymerase and Neq plus DNA polymerases are useful in DNA amplification and PCR-based applications, particularly in clinical diagnoses using uracil-DNA glycosylase.
Purification, crystallization and preliminary crystallographic analysis of a multiple cofactor-dependent DNA ligase from Sulfophobococcus zilligii.
A recombinant DNA ligase from Sulfophobococcus zilligii that shows multiple cofactor specificity (ATP, ADP and GTP) was expressed in Escherichia coli and purified under reducing conditions. Crystals
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