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Myosin light chain kinase mediates intestinal barrier dysfunction via occludin endocytosis during anoxia/reoxygenation injury.
- Younggeon Jin, A. Blikslager
- Biology, Medicine
- American journal of physiology. Cell physiology
- 1 December 2016
Intestinal anoxia/reoxygenation (A/R) injury induces loss of barrier function followed by epithelial repair. Myosin light chain kinase (MLCK) has been shown to alter barrier function via regulation… Expand
Synergistic therapeutic effects of cytokine-induced killer cells and temozolomide against glioblastoma.
The presence of active immunity within the brain supports the possibility of effective immunotherapy for glioblastoma (GBM). To provide a clinically-relevant adoptive immunotherapy for GBM using ex… Expand
ClC-2 regulation of intestinal barrier function: Translation of basic science to therapeutic target
The ClC-2 chloride channel is a member of the voltage-gated chloride channel family. ClC-2 is involved in various physiological processes, including fluid transport and secretion, regulation of cell… Expand
Combined treatment of tumor-tropic human neural stem cells containing the CD suicide gene effectively targets brain tumors provoking a mild immune response.
Previous studies showed promise of coupling genetically engineered neural stem cells (NSCs) with blood-brain barrier permeable prodrugs as an effective anti-brain tumor therapy. Here, we further… Expand
TTAC-0001, a human monoclonal antibody targeting VEGFR-2/KDR, blocks tumor angiogenesis
Angiogenesis is one of the most important processes for cancer cell survival, tumor growth and metastasis. Vascular endothelial growth factor (VEGF) and its receptor, particularly VEGF receptor-2… Expand
Anticancer activity of TTAC-0001, a fully human anti-vascular endothelial growth factor receptor 2 (VEGFR-2/KDR) monoclonal antibody, is associated with inhibition of tumor angiogenesis
Vascular endothelial growth factor (VEGF) and its receptors are considered the primary cause of tumor-induced angiogenesis. Specifically, VEGFR-2/kinase insert domain receptor (KDR) is part of the… Expand
Gene silencing of c-Met leads to brain metastasis inhibitory effects
- Se Jeong Lee, H. Seol, +8 authors D. Nam
- Biology, Medicine
- Clinical & Experimental Metastasis
- 27 April 2013
An unfortunate consequence of improvements in the treatments of advanced primary cancers is the concurrent increase of metastatic brain tumors. Despite of unfavorable clinical prognosis, radiation… Expand
Intestinal Ischemia–Reperfusion: Rooting for the SOCS?
Ischemia–reperfusion (IR) injury of the intestine occurs when blood flow is temporarily interrupted, which occurs during interventions such as surgery for an abdominal aortic aneurysm, small bowel… Expand
Functional neural stem cell isolation from brains of adult mutant SOD1 (SOD1G93A) transgenic amyotrophic lateral sclerosis (ALS) mice
Abstract Objectives: The aim of present study is to investigate more functional neural stem cells (NSCs) could be isolated from brains with amyotrophic lateral sclerosis (ALS) and expanded in vitro,… Expand
Knockout of ClC-2 reveals critical functions of adherens junctions in colonic homeostasis and tumorigenicity.
- Younggeon Jin, Dina S. S. Ibrahim, S. Magness, A. Blikslager
- Chemistry, Medicine
- American journal of physiology. Gastrointestinal…
- 1 December 2018
Adherens junctions (AJs), together with tight junctions (TJs), form an apical junctional complex that regulates intestinal epithelial cell-to-cell adherence and barrier homeostasis. Within the AJ,… Expand