Young Whan Park

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To better understand regulation of eukaryotic protein synthesis, we studied cellular and viral mRNA translation in influenza virus-infected cells. Influenza virus infection results in a dramatic shut-off of cellular protein synthesis that is concomitant with selective viral mRNA translation. Earlier work showed that these events are mediated by viral and/or(More)
We have shown that sequences contained within the viral mRNA 5'-untranslated region (UTR) played a critical role in directing selective influenza viral mRNA translation. We therefore attempted to identify transacting factors that may regulate viral mRNA translation through interactions with the 5'-UTR and at the same time map the precise sequences to which(More)
Methicillin-resistant Staphylococcus aureus (MRSA) is a major nosocomial and community-acquired pathogen for which few existing antibiotics are efficacious. Here we describe two structurally related synthetic compounds that potentiate beta-lactam activity against MRSA. Genetic studies indicate that these agents target SAV1754 based on the following(More)
A fluorescence resonance energy transfer assay has been developed for monitoring Bacillus anthracis lethal factor (LF) protease activity. A fluorogenic 16-mer peptide based on the known LF protease substrate MEK1 was synthesized and found to be cleaved by the enzyme at the anticipated site. Extension of this work to a fluorogenic 19-mer peptide, derived, in(More)
The yeast three-hybrid system presents a valuable tool for detecting and analyzing RNA-protein interactions in vivo. A major drawback of the use of such a transcriptional reporter-based assay in a library screen is the frequent occurrence of false-positive results due to bait RNA-independent activation of the reporter gene. To minimize the isolation of(More)
In this paper, we present a virtual training system which realistically represents the situation of real welding. First of all, we built a database about welding outputs such as the shape of bead which is the deposit outcome resulting from inputs of real welding conditions and operations. Second, we performed an analysis of relations between input variables(More)
Crohn’s disease in humans has strong similarities to Johne’s disease in cattle, but with a poorly defined etiology. Mycobacterium paratuberculosis, the causative agent of Johne’s disease, has been linked as a causal agent of Crohn’s disease in humans. However, evidence to date does not prove that Crohn’s disease is caused by M. paratuberculosis and may, in(More)
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