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Injury to peripheral nerves causes a neuropathic pain which is difficult to relieve, but the underlying mechanism remains largely unknown. In previous studies we reported that voltage-gated potassium (Kv) channel alpha genes are downregulated in the dorsal root ganglia (DRG) following chronic constriction of the sciatic nerve [Kim et al. (2002)], suggesting(More)
The COX-2/PGE₂ pathway has been implicated in the occurrence and progression of cancer. The underlying mechanisms facilitating the production of COX-2 and its mediator, PGE₂, in cancer survival remain unknown. Herein, we investigated PGE₂-induced COX-2 expression and signaling in HL-60 cells following menadione treatment. Treatment with PGE₂ activated(More)
Fatty acids flow from adipocytes to nonadipose tissues during fasting and exercise and normally are fully oxidized. To determine if nonadipose tissues can export unoxidized FA when FA influx exceeds oxidation, neonatal cardiomyocytes were cultured in 1 microCi (14)C-palmitate in the presence of etomoxir to block oxidation. The cells took up and stored 25%(More)
Chlorpyrifos (CPF), an organophosphorus pesticide (OP), is one of the most widely used pesticides in the world. Subchronic exposures to CPF that do not cause cholinergic crisis are associated with problems in cognitive function (i.e., learning and memory deficits), but the biological mechanism(s) underlying this association remain speculative. To identify(More)
Prostaglandin E2 (PGE2) promotes tumor-persistent inflammation, frequently resulting in cancer. Curcumin is a diphenolic turmeric that inhibits carcinogenesis and induces apoptosis. PGE2 inhibits curcumin-induced apoptosis; however, the underlying inhibitory mechanisms in colon cancer cells remain unknown. The aim of the present study is to investigate the(More)
Rapid and accurate detection of airborne micro-particles is currently an important problem in national security. One approach to such detection, bioaerosol mass spec-trometry (BAMS), is currently under development at Lawrence Livermore National Laboratory. BAMS is a type of single particle aerosol mass spectrometry that rapidly records dual-polarity mass(More)
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