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Functional Roles of p38 Mitogen-Activated Protein Kinase in Macrophage-Mediated Inflammatory Responses
Inflammation is a natural host defensive process that is largely regulated by macrophages during the innate immune response. Mitogen-activated protein kinases (MAPKs) are proline-directed serine andExpand
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Caspase‐11 non‐canonical inflammasome: a critical sensor of intracellular lipopolysaccharide in macrophage‐mediated inflammatory responses
Inflammatory responses mediated by macrophages are part of the innate immune system, whose role is to protect against invading pathogens. Lipopolysaccharide (LPS) found in the outer membrane ofExpand
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The Role of Src Kinase in Macrophage-Mediated Inflammatory Responses
Src kinase (Src) is a tyrosine protein kinase that regulates cellular metabolism, survival, and proliferation. Many studies have shown that Src plays multiple roles in macrophage-mediated innateExpand
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Role of ginsenosides, the main active components of Panax ginseng, in inflammatory responses and diseases
Panax ginseng is one of the most universally used herbal medicines in Asian and Western countries. Most of the biological activities of ginseng are derived from its main constituents, ginsenosides.Expand
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Functional Roles of Syk in Macrophage-Mediated Inflammatory Responses
Inflammation is a series of complex biological responses to protect the host from pathogen invasion. Chronic inflammation is considered a major cause of diseases, such as various types ofExpand
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Regulatory Roles of Flavonoids on Inflammasome Activation during Inflammatory Responses
  • Young-Su Yi
  • Biology, Medicine
  • Molecular nutrition & food research
  • 1 July 2018
Inflammation is an innate immune response to noxious stimuli to protect the body from pathogens. Inflammatory responses consist of two main steps: priming and triggering. In priming, inflammatoryExpand
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Folate Receptor-Targeted Diagnostics and Therapeutics for Inflammatory Diseases
  • Young-Su Yi
  • Biology, Medicine
  • Immune network
  • 1 December 2016
Inflammation, an innate immune response mediated by macrophages, forms the first line of defence to protect our body from the invasion of various pathogens. Although inflammation is a defensiveExpand
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BIOGF1K, a compound K-rich fraction of ginseng, plays an antiinflammatory role by targeting an activator protein-1 signaling pathway in RAW264.7 macrophage-like cells
Department of Genetic Engineering, Sungkyunkwan University, Suwon, Republic of Korea Department of Pharmaceutical Engineering, Cheongju University, Cheongju, Republic of Korea Department of Pharmacy,Expand
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Regulatory Roles of the Caspase-11 Non-Canonical Inflammasome in Inflammatory Diseases
  • Young-Su Yi
  • Medicine, Biology
  • Immune network
  • 17 November 2018
Inflammation is an immune response mediated by innate immune cells of tissues, against invading microbes and cellular stress. The hallmark of inflammatory responses is the activation of inflammasomesExpand
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PDK1 disruptors and modulators: a patent review
Introduction: 3-Phosphoinositide-dependent kinase 1 (PDK1) is a master regulator of the AGC protein kinase family and is a critical activator of multiple pro-survival and oncogenic protein kinases,Expand
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