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Brief or prolonged seizures induce various patterns of plasticity. Axonal or dendritic remodelling and development of ectopic granule cells have been described in the hilus and molecular layer of the adult rodent hippocampus. Hippocampal cell proliferation also occurs after seizures. However, whether the seizure-induced cell proliferation plays a(More)
Granulocyte colony-stimulating factor (G-CSF) has been used in the treatment of neutropenia in hematologic disorders. The neuroprotective and anti-inflammatory effects of G-CSF were reported in various neurological disease models. In this study, we examined whether G-CSF induces functional recovery after intracerebral hemorrhage (ICH). ICH was induced using(More)
Ipsilateral hemiparesis after a supratentorial stroke is rare. However, the role of the reorganization of the unaffected hemisphere in recovery after a stroke is poorly understood. Two patients developed ipsilateral hemiparesis after a left corona radiata infarct. Both of these patients had previously experienced contralateral hemiparesis after a(More)
BACKGROUND AND PURPOSE The somatotopic organization of the corticospinal fibers is of importance because it is related to certain stroke syndromes. Although it has been suggested that motor fibers are somatotopically arranged in the corona radiata, the evidence is still insufficient in human. METHODS The relative anteroposterior and mediolateral location(More)
OBJECTIVE To characterise the topographic patterns of thalamic infarcts associated with various stroke syndromes and aetiologies. METHODS In this study, 168 consecutive patients with acute infarcts involving the thalamus were investigated by use of diffusion weighted MR imaging. Involved thalamic territories were classified into four vascular territories:(More)
BACKGROUND The time of neurological improvement (TNI) after acute ischemic stroke may have a predictive value. METHODS We evaluated 410 consecutive patients who were admitted within 12 hours of stroke onset. The National Institutes of Health Stroke Scale (NIHSS) was measured on admission and at 1, 3, 7, and 14 days. Neurological improvement was defined as(More)
Oromandibular dystonia (OMD) is a focal dystonia that is characterized by repetitive or sustained spasms of the masticatory, facial, or lingual muscles. The etiology is idiopathic in most cases. A patient presenting with OMD associated with diabetic hyperglycemia is reported herein. A 74-year-old woman with a history of diabetes developed OMD. Brain MRI(More)
Selective gray-matter involvement has been recognized in global cerebral ischemia, but is not readily acknowledged to occur in focal ischemic stroke. The author reports two patients with acute infarcts that selectively affected the gray matter of the basal ganglia among the striatocapsular areas, but spared the white matter of the internal capsule. The(More)
OBJECTIVE To determine whether the location of subcortical silent infarcts differs from that of symptomatic lacunar infarcts. METHODS 32 silent infarcts and 59 acute lacunar infarcts located in the corona radiata were examined. The relative anterior-to-posterior locations of the silent infarcts in the corona radiata were compared with those of the(More)