Young Min Seo

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The in vitro metabolism of deoxypodophyllotoxin (DPT), a medicinal herbal product isolated from Anthriscus sylvestris (Apiaceae), was investigated in rats and human microsomes and human recombinant cDNA-expressed CYPs. The incubation of DPT with pooled human microsomes in the presence of NADPH generated five metabolites while its incubation with(More)
Carbonyl reduction is a significant step in the phase I biotransformation of a great variety of aromatic, alicyclic and aliphatic carbonyl compounds. 1-Furan-2-yl-3-pyridin-2-yl-propenone (FPP-3) has been shown to have anti-inflammatory activity as it inhibits the production of nitric oxide and tumor necrosis factor-beta. In the present study, the metabolic(More)
Although rutaecarpine, an alkaloid originally isolated from the unripe fruit of Evodia rutaecarpa, has been reported to reduce the systemic exposure of caffeine, the mechanism of this phenomenon is unclear. We investigated the microsomal enzyme activity using hepatic S-9 fraction and the plasma concentration-time profiles and urinary excretion of caffeine(More)
 Key features desired from IMT-Advanced network include open architecture for productivity, increased end-user throughput, reduced latency, support for full mobility and end-to-end QoS. A femtocell is a small cellular base station designed for use in residential or small business environments. It connects to the service provider’s network via broadband(More)
Measurement of Quality of Service (QoS) parameters and its statistical analysis becomes a key issue for Mobile WiMAX service providers to manage the network efficiently and to support end-to-end Quality of Experience (QoE). On the other hand, for the measurement of QoS parameters, economy (memory space), timelines and accuracy are the primary concerns.(More)
metabolized by hepatic CYP1A2 and CYP2E1 (Caubet et al., 2004). Thereby, N-demethylations of caffeine have been used as marker reactions for some CYPs: 3-N-demethylation to paraxanthine catalyzed by CYP1A2 and 1-N-demethylation to theobromine and 7-N-demethylation to theophylline catalyzed by CYP2E1. Furthermore, caffeine and its three major metabolites(More)
PURPOSE This study was conducted to identify comprehensive predictors of fatigue in cancer patients. METHODS One hundred ten cancer patients visiting in-patient or out-patient clinics of a university hospital located in Incheon participated in this study. RESULTS The hematologic indicators (WBC and Hemoglobin) were significant for explaining fatigue.(More)
Halogenated organic compounds, such as 1-bromopentane (1-BPT), are used as cleaning agents, synthesis agents, or extraction solvents in the workplace. In the present study, glutathione (GSH) conjugation and hepatotoxicity induced by 1-BPT were investigated in female BALB/c mice. S-Bromopentyl GSH, S-bromopentyl cysteine, and mono-hydroxypentyl mercapturic(More)
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