Young-Mi Lee

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Wnt/β-catenin signaling plays important roles in cutaneous wound healing and dermal fibrosis. However, its regulatory mechanism has not been fully elucidated, and a commercially available wound-healing agent targeting this pathway is desirable but currently unavailable. We found that CXXC-type zinc finger protein 5 (CXXC5) serves as a negative feedback(More)
BACKGROUND Animal studies indicate that postnatal adaptation and development of neonates could be different due to the birth method and that these effects may last throughout adulthood. STUDY DESIGN We applied a spatio-temporal analysis to EEG recordings of a group of neonates to investigate the influence of a cesarean section on maturation and(More)
Platycodon grandiflorum (Campanulaceae) is used as traditional medicine in Asian countries. In Korean traditional medicine, Platycodon root has been widely used since ancient times as a traditional drug to treat cold, cough and asthma. However, its effects on bone marrow-derived mast cell (BMMC)-mediated allergy and inflammation mechanisms remain unknown.(More)
The present study investigated the role of extra-cellular signal-regulated kinase (ERK) activation in the migratory phenotype of human U2OS osteosarcoma (OS) cells in a collagen matrix. The activation of ERK was inhibited by PD98059, a specific inhibitor of ERK kinase. Additionally, no significant differences were observed in the adhesion and proliferation(More)
Location-dependent skin surface's partial nitric oxide pressure (pNO) is studied using highly sensitive amperometric NO microsensor with a small sensing area (diameter  = 76 μm). The pNO level of LI4 (Hegu) acupuncture point is measured and compared with the pNO level of nonacupuncture point. In addition, the mapping of pNO is carried out over the left(More)
Aim. To compare two creatinine-based estimated glomerular filtration rate (eGFR) equations, the chronic kidney disease epidemiology collaboration (CKD-EPI) and the modification of diet in renal disease (MDRD), for predicting the risk of CKD progression in type 2 diabetic patients with nephropathy. Methods. A total of 707 type 2 diabetic patients with 24 hr(More)
Despite marked advances in breast cancer therapy, basal-like breast cancer (BBC), an aggressive subtype of breast cancer usually lacking estrogen and progesterone receptors, remains difficult to treat. In this study, we report the identification of MELK as a novel oncogenic kinase from an in vivo tumorigenesis screen using a kinome-wide open reading frames(More)
Heat shock proteins play an important role in protein homeostasis under stress conditions, and act as molecular chaperons in living organisms. Here, we investigate acute toxicity of heavy metals (Cu and Cd) and the transcriptional changes of the heat shock proteins (hsps) family genes (hsp20, hsp27, hsp70, hsp90α-1, and hsp90β) in Brachionus(More)
3-AFC discrimination tests between 2 confusable versions of apple juice were performed using a variety of interstimulus rinsing regimes, to investigate the effects of order of tasting on difference test sensitivity. The results were compared to predictions from the sequential sensitivity analysis (SSA) model and the conditional stimulus (CS) model, which(More)
BACKGROUND Caspase-3, a principal apoptotic effector that cleaves the majority of cellular substrates, is an important medicinal target for the treatment of cancers and neurodegenerative diseases. Large amounts of the protein are required for drug discovery research. However, previous efforts to express the full-length caspase-3 gene in E. coli have been(More)