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A massive hexanucleotide repeat expansion mutation (HREM) in C9ORF72 has recently been linked to amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Here we describe the frequency, origin and stability of this mutation in ALS+/−FTD from five European cohorts (total n=1347). Single-nucleotide polymorphisms defining the risk haplotype in(More)
ATAM helps stakeholders determine where the risks and tradeoffs exist in elicited architectural strategies. But it provides no guidance for understanding economic benefits, thus needs to be complemented by some quantitative approach. CBAM helps software architects consider the return-on-investment of any architectural decision and provides guidance on the(More)
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