Youichi Morimoto

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BACKGROUND & AIMS We evaluated whether spleen stiffness (SS), measured by acoustic radiation force impulse imaging, can identify patients who have esophageal varices (EVs); those without EVs would not require endoscopic examination. METHODS In a prospective study, we measured SS and liver stiffness (LS) in 340 patients with cirrhosis undergoing endoscopic(More)
PURPOSE To retrospectively compare the outcome of combined transcatheter arterial chemoembolization (TACE) and radiofrequency ablation (RFA) (hereafter, TACE-RFA) with that of surgical resection (SR) in patients with hepatocellular carcinoma (HCC) within the Milan criteria. MATERIALS AND METHODS Institutional review board approval and informed consent(More)
PURPOSE To evaluate the accuracy of spleen stiffness (SS) and liver stiffness (LS) measured by using acoustic radiation force impulse imaging in the diagnosis of portal hypertension in patients with liver cirrhosis, with the hepatic venous pressure gradient (HVPG) as a reference standard. MATERIALS AND METHODS Institutional review board approval and(More)
BACKGROUND/AIMS Survival predictors in patients with ruptured hepatocellular carcinoma (HCC) treated by transarterial embolization (TAE), have not been fully investigated. METHODOLOGY Predictors of short-term (< or = 30 days) and long-term (>30 days) survival were evaluated by using the logistic regression model and the Cox proportional hazard model,(More)
BACKGROUND & AIMS Hepatic venous pressure gradient can predict mortality and hepatic decompensation in patients with cirrhosis. Measurement of hepatic venous pressure gradient requires an invasive procedure; therefore, prognostic markers are needed that do not require invasive procedures. We investigated whether measurements of spleen stiffness, made by(More)
Fulminant hepatic failure (FHF) was produced in rats with intraperitoneal injection of Dgalactosamine.15NH4C1 (50 mg/kg of body weight) was injected into the rats via the tail vein. Arterial blood was drawn before and 5,15, 30, 60 min after the injection of15NH4C1.15N-ammonia, -urea, and-glutamine (amide and amino) were determined by gas chromatography and(More)
AIM To investigate factors that accurately predict hepatocellular carcinoma (HCC) development after antiviral therapy in chronic hepatitis C (CHC) patients. METHODS CHC patients who received pegylated interferon and ribavirin were enrolled in this cohort study that investigated the ability of alpha-fetoprotein (AFP) to predict HCC development after(More)
BACKGROUND AND AIM The prognosis of cryptogenic cirrhosis-associated hepatocellular carcinoma (CC-HCC) was reported to be poor because many of them were discovered at the advanced stage. The aim of this study is to reveal the clinical features of early CC-HCC. METHODS Consecutive 36 curatively treated CC-HCC patients satisfying the Milan Criteria were(More)